Search results for PIP4K2B

Showing 17 results out of 20

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Protein (3 results from a total of 3)

Identifier: R-HSA-1806208
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: PIP4K2B: P78356
Identifier: R-HSA-6811503
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: PIP4K2B: P78356
Identifier: R-HSA-8877679
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: P78356

Interactor (1 results from a total of 1)

Identifier: P78356-2
Species: Homo sapiens
Primary external reference: UniProt: P78356-2

Set (2 results from a total of 2)

Identifier: R-HSA-8877683
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-8877680
Species: Homo sapiens
Compartment: nucleoplasm

Reaction (5 results from a total of 5)

Identifier: R-HSA-8877692
Species: Homo sapiens
Compartment: nucleoplasm
Peptidyl-prolyl cis-trans isomerase PIN1 binds to PIP4K2B phosphorylated at serine residue S326. PIP4K2B is phosphorylated at S326 under conditions of cellular stress, such as increased level of reactive oxygen species (ROS). Phosphorylation of PIP4K2B at threonine residue T322 may also contribute to PIN1 binding. PIN1 induces conformational change of PIP4K2B, resulting in inactivation of PIP4K2B dimers. This enables increase of the nuclear PI5P levels. PI5P positively regulates expression of genes involved in neutralization of ROS (Keune et al. 2012).
Identifier: R-HSA-8877691
Species: Homo sapiens
Compartment: nucleoplasm
Under conditions of cellular stress, such as increased level of reactive oxygen species, MAP2K6 (MKK6), and possibly other kinases of the p38 MAPK family, phosphorylates PIP4K2B at serine residue S326. Threonine residue T322 of PIP4K2B is also phosphorylated under stress conditions, but the responsible kinase is not known. MAP2K6 may also phosphorylate PIP4K2A, but not PIP4K2C (Kuene et al. 2012).
Identifier: R-HSA-6811522
Species: Homo sapiens
Compartment: nucleoplasm
In the nucleus, phosphatidylinositol 5-phosphate (PI5P) is phosphorylated to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) mainly by phosphatidylinositol-5-phosphate 4-kinase type-2 beta (PIP4K2B). In the nucleus, PIP4K2B predominantly functions as a homodimer or a heterodimer with PIP4K2A. A low level of PIP4K2A homodimers can also be found in the nucleus. Nuclear localization of PIP4K2C has not been examined but is assumed to be possible, at least through formation of heterodimers with PIP4K2B (Ciruela et al. 2000, Jones et al. 2006, Bultsma et al. 2010). Under conditions of cellular stress, nuclear PIP4K2B can be phosphorylated by p38 MAP kinases, resulting in PIP4K2B inactivation. The putative p38 target site, serine residue S326 of PIP4K2B, is conserved in PIP4K2A, but the role and mechanism of p38-mediated regulation of PIP4K2 isoforms has not been studied in detail (Jones et al. 2006).
Identifier: R-HSA-1675776
Species: Homo sapiens
Compartment: plasma membrane, cytosol
At the plasma membrane, phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (PIP4K2A), beta (PIP4K2B) and gamma (PIP4K2C) homodimers and heterodimers (Clarke et al. 2010, Clarke and Irvine 2013, Clarke et al. 2015) phosphorylate phosphatidylinositol 5-phosphate (PI5P) to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2).

The following lists the above proteins with their corresponding literature references: PIP4K2A (Rameh et al. 1997, Clarke et al. 2008, Clarke and Irvine 2013), PIP4K2B (Rameh et al. 1997, Clarke and Irvine 2013) and PIP4K2C (Clarke and Irvine 2013, Clarke et al. 2015).
Identifier: R-HSA-1676145
Species: Homo sapiens
Compartment: plasma membrane, cytosol
At the plasma membrane, phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (PIP4K2A) and beta (PIP4K2B) homodimers and heterodimers (Clarke et al. 2010), along with phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (PIP5K1A), beta (PIP5K1B), and gamma (PIP5K1C) phosphorylate phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2).

The following lists the above proteins with their corresponding literature references: PIP4K2A (Zhang et al. 1997, Rameh et al. 1997, Clarke et al. 2008), PIP4K2B (Zhang et al. 1997, Rameh et al. 1997), PIP5K1A (Zhang et al. 1997, Tolias et al. 1998), PIP5K1B (Zhang et al. 1997, Tolias et al. 1998), and PIP5K1C (Wenk et al. 2001, Di Paolo et al. 2002).

Complex (5 results from a total of 8)

Identifier: R-HSA-8877687
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-8877681
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-8877690
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-6808599
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-1806168
Species: Homo sapiens
Compartment: cytosol

Pathway (1 results from a total of 1)

Identifier: R-HSA-8847453
Species: Homo sapiens
Under conditions of cellular stress, nuclear levels of phosphatidylinositol-5-phosphate (PI5P) increase. Type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase TMEM55B translocates to the nucleus under stress via an unknown mechanism (Zou et al. 2007) and generates PI5P from the PI(4,5)P2 substrate. The level of PI5P in the nucleus is kept low because of the phosphatidylinositol-5-phosphate 4-kinase activity of nuclear PIP4K2 dimers, mainly dimers containing PIP4K2B (Ciruela et al. 2000). Under conditions of cellular stress, nuclear PIP4K2B is phosphorylated and inactivated by p38 MAP family kinases (Jones et al. 2006).
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