Search results for PLA2G4A
Showing 16 results out of 21
Protein (4 results from a total of 4)
Identifier: R-HSA-378502
Species:
Homo sapiens
Compartment:
cytosol
Primary external reference: UniProt: PLA2G4A:
P47712
Identifier: R-HSA-1524099
Species:
Homo sapiens
Compartment:
mitochondrial inner membrane
Primary external reference: UniProt: PLA2G4A:
P47712
Identifier: R-HSA-934669
Species:
Homo sapiens
Compartment:
endoplasmic reticulum membrane
Primary external reference: UniProt: PLA2G4A:
P47712
Identifier: R-HSA-111859
Species:
Homo sapiens
Compartment:
endoplasmic reticulum membrane
Primary external reference: UniProt: PLA2G4A:
P47712
Reaction (10 results from a total of 15)
Identifier: R-HSA-1482759
Species:
Homo sapiens
Compartment:
mitochondrial inner membrane,
mitochondrial matrix
At the inner mitochondrial membrane (IM), the phospholipase A2 group IV alpha (PLA2G4A) protein hydrolyzes monolysocardiolipin (MLCL) and produces dilysocardiolipin (DLCL) (Buckland et al. 1998, Sharp et al. 1994).
Identifier: R-HSA-111883
Species:
Homo sapiens
Compartment:
endoplasmic reticulum membrane,
cytosol,
endoplasmic reticulum lumen
Once bound to the membrane, cPLA2 hydrolyzes phosphatidylcholine to produce arachidonic acid (AA), a precursor to inflammatory mediators. While several phospholipases can catalyze this reaction in cells overexpressing the enzymes, PLA2G4A is the major enzyme that catalyzes this reaction in vivo (Reed et al. 2011). At the same time, possible physiological roles have been described for soluble phospholipases (sPLA) in the mobilization of arachidonic acid in some cell types or under some physiological conditions (Murakami et al. 2011). Here, the major role of PLA2G4A has been annotated.
Identifier: R-HSA-1482900
Species:
Homo sapiens
Compartment:
endoplasmic reticulum membrane,
cytosol
At the endoplasmic reticulum (ER) membrane, phosphatidylglycerol (PG) is hydrolyzed, and has one of its acyl chains cleaved off, by cytosolic phospholipase A2 alpha/beta/delta/zeta (PLA2G4A/B/D/F) (Ghomashchi et al. 2010) to form 1-acyl lysophosphatidylglycerol (LPG).
Identifier: R-HSA-1482656
Species:
Homo sapiens
Compartment:
cytosol,
endoplasmic reticulum membrane
At the endoplasmic reticulum (ER) membrane, phosphatidic acid (PA) is hydrolyzed, and has one of its acyl chains cleaved off, by phospholipase A2 alpha/beta/delta/zeta (PLA2G4A/B/D/F) to form 1-acyl lysophosphatidic acid (LPA) (Ghomashchi et al. 2010).
Identifier: R-HSA-1482604
Species:
Homo sapiens
Compartment:
mitochondrial outer membrane,
cytosol
At the outer mitochondrial (OM) membrane, phosphatidic acid (PA) is hydrolyzed, and has one of its acyl chains cleaved off, by phospholipase A2 alpha/beta/delta/zeta (PLA2G4A/B/D/F) to form 1-acyl lysophosphatidic acid (LPA) (Ghomashchi et al. 2010).
Identifier: R-HSA-1482771
Species:
Homo sapiens
Compartment:
endoplasmic reticulum membrane,
cytosol
At the endoplasmic reticulum (ER) membrane, phosphatidylserine (PS) is hydrolyzed, and has one of its acyl chains cleaved off, by cytosolic phospholipase A2 alpha/beta/delta/epsilon/zeta (PLA2G4A,B,D/E/F) (Ghomashchi et al. 2010), or by group XVI phospholipase A2 (PLA2G16) (Duncan et al. 2008). This produces 1-acyl lysophosphatidylserine (LPS).
Identifier: R-HSA-1482828
Species:
Homo sapiens
Compartment:
endoplasmic reticulum membrane,
cytosol
At the endoplasmic reticulum (ER) membrane, phosphatidylethanolamine (PE) is hydrolyzed, and has one of its acyl chains cleaved off by cytosolic phospholipase A2 alpha/delta/epsilon/zeta (PLA2G4A/D/E/F) (Ghomashchi et al. 2010). This produces 2-acyl lysophosphatidylethanolamine (LPE). Cytosolic phospholipase A2 enzymes show not only PLA2 hydrolyzing activity to form the 1-acyl lysophospholipid but also have a degree of PLA1 activity, producing a 2-acyl lysophospholipid.
Identifier: R-HSA-1482897
Species:
Homo sapiens
Compartment:
endoplasmic reticulum membrane,
cytosol
At the endoplasmic reticulum (ER) membrane, phosphatidylserine (PS) is hydrolyzed, and has one of its acyl chains cleaved off, by cytosolic phospholipase A2 alpha/delta/zeta (PLA2G4A/D/F) (Ghomashchi et al. 2010). This produces 2-acyl lysophosphatidylserine (LPS). Cytosolic phospholipase A2 enzymes show not only PLA2 hydrolyzing activity to form the 1-acyl lysophospholipid but also have a degree of PLA1 activity, producing a 2-acyl lysophospholipid.
Identifier: R-HSA-1482862
Species:
Homo sapiens
Compartment:
endoplasmic reticulum membrane,
cytosol
At the endoplasmic reticulum (ER) membrane, phosphatidylcholine (PC) is hydrolysed, and has one of its acyl chains cleaved off, by cytosolic phospholipase A2 alpha/beta/delta/epsilon/zeta (PLA2G4A/B/D/E/F) (Ghomashchi et al. 2010). This produces 2-acyl lysophosphatidylcholine (LPC). Cytosolic phospholipase A2 enzymes show not only PLA2 hydrolysing activity to form the 1-acyl lysophospholipid but also have a degree of PLA1 activity, producing a 2-acyl lysophospholipid.
Identifier: R-HSA-1482612
Species:
Homo sapiens
Compartment:
endoplasmic reticulum membrane,
cytosol
At the endoplasmic reticulum (ER) membrane, 2-acyl lysophosphatidylcholine (LPC) is hydrolyzed to glycerophosphocholine (GPCho) by cytosolic phospholipase A2 alpha/beta/delta/epsilon/zeta (PLA2G4A/B/D/E/F) (Yamashita et al. 2005, Ghomashchi et al. 2010, Yamashita et al. 2009, Sharp et al. 1994) or by Phospholipase B1-like (PLBD1) (Xu et al. 2009). PLBD1 also acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction.
Complex (2 results from a total of 2)
Identifier: R-HSA-1500626
Species:
Homo sapiens
Compartment:
cytosol
Identifier: R-HSA-1524095
Species:
Homo sapiens
Compartment:
mitochondrial inner membrane
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