Search results for PLCB1

Showing 6 results out of 6

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Species

Types

Compartments

Search properties

Protein (1 results from a total of 1)

Identifier: R-HSA-61693
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: PLCB1: Q9NQ66

Complex (1 results from a total of 1)

Identifier: R-HSA-1604622
Species: Homo sapiens
Compartment: cytosol

Pathway (1 results from a total of 1)

Identifier: R-HSA-418217
Species: Homo sapiens
Compartment: cytoplasmic side of plasma membrane
Phospholipase C beta (PLCbeta) isoforms are activated by G-protein beta:gamma in the order PLCB3 > PLCB2 > PLCB1. Gbeta:gamma binds to the pleckstrin homology domain of PLC beta, increasing phospholipase activity and leading to increased hydrolysis of PIP2 to DAG and IP3.

Reaction (1 results from a total of 1)

Identifier: R-HSA-1855177
Species: Homo sapiens
Compartment: cytosol, plasma membrane
At the plasma membrane, a group of phospholipase C (“PLC(bz))” proteins hydrolyse phosphatidylinositol 4,5 bisphosphate (PI(4,5)P2) to inositol 1,4,5 trisphosphate (I(1,4,5)P3) and diacylglycerol (DAG). This group of phospholipase C proteins lack a PH domain and so are is cytosolic. Their C2 domains bind to PI(4,5)P2 at the membrane. The PLC-beta proteins are thought to be responsible for the majority of PI(4,5)P2 hydrolysis.

The phospholipase C isoforms involved and their corresponding literature references are: phosphoinositide phospholipase C beta-1 (PLCB1) (Caricasole et al. 2000, Jhon et al. 1993, Park et al. 1992); beta-2 (PLCB2) (Jhon et al. 1993, Park et al. 1992); beta-3 (PLCB3) (Carozzi et al. 1992, Jhon et al. 1993); beta-4 (PLCB4) (Alvarez et al. 1995, Lee et al. 1993); and zeta-1 (PLCZ1) (Kouchi et al. 2005, Rogers et al. 2004).

Icon (2 results from a total of 2)

Species: Homo sapiens
Curator: Steve Jupe
Designer: Cristoffer Sevilla
PLCB1 icon
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Species: Homo sapiens
Curator: Steve Jupe
Designer: Cristoffer Sevilla
PLCB1,2,3 icon
Set of Phospholipase C beta 1,2 and 3
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