Search results for PLCE1

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Species

Types

Compartments

Search properties

Protein (1 results from a total of 1)

Identifier: R-HSA-2023890
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: PLCE1: Q9P212

Complex (1 results from a total of 1)

Identifier: R-HSA-2023865
Species: Homo sapiens
Compartment: plasma membrane

Reaction (1 results from a total of 1)

Identifier: R-HSA-1855221
Species: Homo sapiens
Compartment: plasma membrane, cytosol
A group of phospholipase C proteins (“PLC(degh)”) bind to the plasma membrane via their PH domains. These phospholipases hydrolyse phosphatidylinositol 4,5 bisphosphate (PI(4,5)P2) to inositol 1,4,5 trisphosphate (I(1,4,5)P3) and diacylglycerol (DAG). The C2 domains of the enzymes bind to PI(4,5)P2 at the membrane.

The phospholipase C isoforms involved and their corresponding literature references are: phosphoinositide phospholipase C delta-1(PLCD1) (Cheng et al. 1995); epsilon-1 (PLCE1) (Song et al. 2001, Lopez et al. 2001); delta-3 (PLCD3) (Pawelczyk & Matecki 1997); gamma-1 (PLCG1) (Harita et al. 2009, Baldassare et al. 1989); gamma-2 (PLCG2) (Banno et al. 1988); eta-1 (PLCH1) (Hwang et al. 2005); and eta-2 (PLCH2) (Zhou et al 2005).
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