Search results for PMPCA

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Species

Types

Compartments

Reaction types

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Protein (1 results from a total of 1)

Identifier: R-HSA-1299450
Species: Homo sapiens
Compartment: mitochondrial inner membrane
Primary external reference: UniProt: PMPCA: Q10713

Reaction (2 results from a total of 2)

Identifier: R-HSA-8949649
Species: Homo sapiens
Compartment: mitochondrial inner membrane
The mitochondrial endopeptidase PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) yielding SMDT1 (Konig et al. 2016). Mature SMDT1 is assembled into the MCU complex where it serves to bridge the MCU pore and the MCU regulators MICU1 and MICU2 (or MICU3 in neurons).
Identifier: R-HSA-8949668
Species: Homo sapiens
Compartment: mitochondrial inner membrane
ProSMDT1 (proEMRE) that is not bound by C2orf47:AFG3L2 and processed by PMPCA,B is proteolyzed by YME1L1 (Konig et al. 2016) in a large complex containing STOML2 (SLP2) and PARL (Wai et al. 2016). Thus YME1L1 appears to prevent accumulation of proSMDT1.
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