Search results for PPM1L

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Protein (1 results from a total of 1)

Identifier: R-HSA-429688
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: PPM1L: Q5SGD2

Complex (1 results from a total of 1)

Identifier: R-HSA-429703
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane

Reaction (5 results from a total of 5)

Identifier: R-HSA-429732
Species: Homo sapiens
Compartment: cytosol, endoplasmic reticulum membrane
Multiphospho-CERT retains its affinity for VAPA or VAPB (VAMP-associated proteins A or B) and PPM1L (protein phosphatase 1-like) in the endoplasmic reticulum membrane, and can associate with them to form a membrane-associated complex (Saito et al. 2008).
Identifier: R-HSA-429730
Species: Homo sapiens
Compartment: cytosol, endoplasmic reticulum membrane
PPM1L (protein phosphatase 1-like) catalyzes the dephosphorylation of multiphospho-“CERT” (ceramide transfer protein) that is complexed with it in the endoplasmic reticulum membrane (Saito et al. 2008).
Identifier: R-HSA-429694
Species: Homo sapiens
Compartment: cytosol, endoplasmic reticulum membrane
“CERT” (ceramide transfer protein) can dissociate from its complex in the endoplasmic reticulum membrane with VAPA or VAPB (VAMP-associated proteins A or B) and PPM1L (protein phosphatase 1-like) and is released into the cytosol (Kawano et al. 2006).
Identifier: R-HSA-429699
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
CERT (ceramide transfer protein), an isoform of COL4A3BP, mediates the translocation of ceramides from the endoplasmic reticulum (ER) membrane to the membrane of the Golgi apparatus. Immunoprecipitation experiments suggest that CERT is associated with the ER membrane as part of a complex with PPM1L (protein phosphatase 1-like) (Saito et al. 2008) and VAPA or VAPB (VAMP-associated proteins A or B) (Kawano et al. 2006). The carboxyterminal START domain of CERT protein specifically binds ceramides (Hanada et al. 2003; Kudo et al. 2008).
Identifier: R-HSA-429683
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
“CERT” (ceramide transfer protein), associated with the cytosolic face of the endoplasmic reticulum (ER) in a complex with VAPA or VAPB (VAMP-associated proteins A or B) (Kawano et al. 2006) and PPM1L (protein phosphatase 1-like) (Saito et al. 2008), can bridge the gap between the ER and the Golgi apparatus via its PH domain and transfer a molecule of ceramide extracted from the ER membrane to the Golgi (Hanada et al. 2003; Saito et al. 2008). “CERT”-mediated ceramide transfer is positively regulated by OSBP (oxysterol binding protein), by an unknown mechanism (Perry and Ridgway 2006).

Pathway (1 results from a total of 1)

Identifier: R-HSA-428157
Species: Homo sapiens
Sphingolipids are derivatives of long chain sphingoid bases such as sphingosine (trans-1,3-dihydroxy 2-amino-4-octadecene), an 18-carbon unsaturated amino alcohol which is the most abundant sphingoid base in mammals. Amide linkage of a fatty acid to sphingosine yields ceramides. Esterification of phosphocholine to ceramides yields sphingomyelin, and ceramide glycosylation yields glycosylceramides. Introduction of sialic acid residues yields gangliosides. These molecules appear to be essential components of cell membranes, and intermediates in the pathways of sphingolipid synthesis and breakdown modulate processes including apoptosis and T cell trafficking.

While sphingolipids are abundant in a wide variety of foodstuffs, these dietary molecules are mostly degraded by the intestinal flora and intestinal enzymes. The body primarily depends on de novo synthesis for its sphingolipid supply (Hannun and Obeid 2008; Merrill 2002). De novo synthesis proceeds in four steps: the condensation of palmitoyl-CoA and serine to form 3-ketosphinganine, the reduction of 3-ketosphinganine to sphinganine, the acylation of sphinganine with a long-chain fatty acyl CoA to form dihydroceramide, and the desaturation of dihydroceramide to form ceramide.

Other sphingolipids involved in signaling are derived from ceramide and its biosynthetic intermediates. These include sphinganine (dihydrosphingosine) 1-phosphate, phytoceramide, sphingosine, and sphingosine 1-phosphate.

Sphingomyelin is synthesized in a single step in the membrane of the Golgi apparatus from ceramides generated in the endoplasmic reticulum (ER) membrane and transferred to the Golgi by CERT (ceramide transfer protein), an isoform of COL4A3BP that is associated with the ER membrane as a complex with PPM1L (protein phosphatase 1-like) and VAPA or VAPB (VAMP-associated proteins A or B). Sphingomyelin synthesis appears to be regulated primarily at the level of this transport process through the reversible phosphorylation of CERT (Saito et al. 2008).

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