Search results for PREB

Showing 8 results out of 8

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Species

Types

Compartments

Reaction types

Search properties

Protein (1 results from a total of 1)

Identifier: R-HSA-203984
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: PREB: Q9HCU5

DNA Sequence (1 results from a total of 1)

Identifier: R-HSA-5642257
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSEMBL:ENSG00000138073

Reaction (4 results from a total of 4)

Identifier: R-HSA-5694433
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
MIA2 (also known as CTAGE5), a transmembrane ER protein with roles in collagen secretion, recruits the SAR1 GEF PREB (also known as SEC12) to ER exit sites (Saito et al, 2014).
Identifier: R-HSA-983426
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane, integral component of lumenal side of endoplasmic reticulum membrane, cytosol, endoplasmic reticulum lumen
The cytoplasmic tails of MHC class I molecules do not possess any of the known ER export sequences. BAP31 acts as a cargo receptor by exporting peptide-loaded class I MHC molecules to the ER exit sites or ER/Golgi intermediate compartment. Sec24 of the Sec23-Sec24/Sar1-GTP complex catches cargo by direct contact, forming the prebudding complex. Sar1/Sec23-Sec24 can bring about curvature of the membrane in the formation of vesicle. The cargo (antigen-bound MHC) accumulates within the COPII vesicle by binding to the Sec24 polypeptide of the COPII coat.

SARS-CoV-2 ORF8 (8) induces BECN1-dependent autophagy to degrade class I MHC leading to impaired antigen presentation (Zhang Y et al. 2021).

Identifier: R-HSA-983425
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane, cytosol, endoplasmic reticulum lumen
Sec13-Sec31 binds the prebudding complex and this Sec13-Sec31 heterotetramer forms the outer structural scaffold of the coat. Sec13-Sec31 is likely to crosslink the prebudding complexes generating COPII-coated vesicles.
Identifier: R-HSA-203977
Species: Homo sapiens
Compartment: cytosol, endoplasmic reticulum membrane
SAR1-GDP is recruited to the ER membrane by the transmembrane GEF (Guanine nucleotide exchange factor) PREB (also known as SEC12), where it is converted to SAR1-GTP. PREB itself is recruited to ER exit sites through interaction with MIA2 (also known as CTAGE5).

Complex (2 results from a total of 2)

Identifier: R-HSA-5694290
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Identifier: R-HSA-5694288
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
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