Search results for PROC

Showing 22 results out of 317

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Species

Types

Compartments

Reaction types

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Protein (3 results from a total of 16)

Identifier: R-HSA-8956772
Species: Homo sapiens
Compartment: endoplasmic reticulum lumen
Primary external reference: UniProt: PROC: P04070
Identifier: R-HSA-141042
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: PROC: P04070
Identifier: R-HSA-159730
Species: Homo sapiens
Compartment: endoplasmic reticulum lumen
Primary external reference: UniProt: PROC: P04070

Reaction (3 results from a total of 109)

Identifier: R-HSA-159795
Species: Homo sapiens
Compartment: endoplasmic reticulum lumen, endoplasmic reticulum membrane
GGCX (gamma glutamyl carboxylase) in the endoplasmic reticulum gamma-carboxylates eight glutamate residues on 3D-PROC(33-197) (pro-protein C light chain). MK4 (vitamin K hydroquinone) is oxidized to MK4 epoxide in the process (Berkner 2000; Furie et al. 1999; Stenina et al. 2001; Morris et al. 1995).
Identifier: R-HSA-933523
Species: Homo sapiens
Compartment: cytosol, mitochondrial outer membrane
Procaspase-8/10 undergo dimerization and the subsequent conformational changes at the receptor complex results in the formation of catalytic active caspase dimers.
Identifier: R-HSA-141040
Species: Homo sapiens
Compartment: extracellular region, plasma membrane
Thrombin complexed with thrombomodulin at the endothelial cell surface cleaves the heavy chain of protein C, generating activated protein C and an activation peptide. The activation peptide has no known function.

Set (3 results from a total of 23)

Identifier: R-HSA-204948
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-381935
Species: Homo sapiens
Compartment: extracellular region
Identifier: R-HSA-933469
Species: Homo sapiens
Compartment: cytosol

Complex (3 results from a total of 117)

Identifier: R-HSA-5603321
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-68451
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-2671817
Species: Homo sapiens
Compartment: cytosol

Pathway (3 results from a total of 44)

Identifier: R-HSA-69416
Species: Homo sapiens
Procaspase-8 monomers undergo dimerization. The dimerization event occurs at death-inducing signaling complex (DISC) and results in a reposition of the procaspase-8 inter-subunit linker to become accessible for intermolecular processing by the associated procaspase-8 molecule [Keller N et al 2010; Oberst A et al 2010].
Identifier: R-HSA-9648002
Species: Homo sapiens
RAS proteins undergo several processing steps during maturation including farnesylation, carboxy-terminal cleavage and carboxymethylation, among others. These steps are required for their membrane localization and function and ultimately for their ability to activate RAF (reviewed in Gysin et al, 2011; Ahearn et al, 2018).
Identifier: R-HSA-167060
Species: Homo sapiens
All neurotrophins (NTs) are generated as pre-pro-neurotrophin precursors. The signal peptide is cleaved off as NT is associated with the endoplasmic reticulum (ER). The resulting pro-NT can form a homodimer spontaneously which then transits to the Golgi apparatus and then onto the trans-Golgi network (TGN). Resident protein convertases (PCs) can cleave off the pro-sequence and mature NT is is targeted to constitutively released vesicles. The pro-NT form can also be released to the extracellular region.

Chemical Compound (2 results from a total of 2)

Identifier: R-ALL-446596
Compartment: extracellular region
Primary external reference: ChEBI: procainamide: 8428
Identifier: R-ALL-446598
Compartment: cytosol
Primary external reference: ChEBI: 8428

OtherEntity (2 results from a total of 2)

Identifier: R-ALL-5694171
Compartment: endoplasmic reticulum membrane
Identifier: R-ALL-113717
Compartment: nucleoplasm

Icon (3 results from a total of 4)

Species: Homo sapiens
Curator: Steve Jupe
Designer: Cristoffer Sevilla
Procollagen icon
Pro collagen
Designer: Cristoffer Sevilla
Process arrow icon
An arrow that represents a single or a multiple processes of one or more elements
Designer: Cristoffer Sevilla
No process arrow icon
An arrow that represents that a single or multiple processes are not happening due to a disease related process
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