Search results for PROC

Showing 23 results out of 320

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Species

Types

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Protein (3 results from a total of 16)

Identifier: R-HSA-8956772
Species: Homo sapiens
Compartment: endoplasmic reticulum lumen
Primary external reference: UniProt: PROC: P04070
Identifier: R-HSA-159779
Species: Homo sapiens
Compartment: Golgi lumen
Primary external reference: UniProt: PROC: P04070
Identifier: R-HSA-141042
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: PROC: P04070

Reaction (3 results from a total of 109)

Identifier: R-HSA-159795
Species: Homo sapiens
Compartment: endoplasmic reticulum lumen, endoplasmic reticulum membrane
GGCX (gamma glutamyl carboxylase) in the endoplasmic reticulum gamma-carboxylates eight glutamate residues on 3D-PROC(33-197) (pro-protein C light chain). MK4 (vitamin K hydroquinone) is oxidized to MK4 epoxide in the process (Berkner 2000; Furie et al. 1999; Stenina et al. 2001; Morris et al. 1995).
Identifier: R-HSA-933523
Species: Homo sapiens
Compartment: cytosol, mitochondrial outer membrane
Procaspase-8/10 undergo dimerization and the subsequent conformational changes at the receptor complex results in the formation of catalytic active caspase dimers.
Identifier: R-HSA-141040
Species: Homo sapiens
Compartment: extracellular region, plasma membrane
Thrombin complexed with thrombomodulin at the endothelial cell surface cleaves the heavy chain of protein C, generating activated protein C and an activation peptide. The activation peptide has no known function.

Complex (3 results from a total of 117)

Identifier: R-HSA-5603321
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-6790891
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-5603469
Species: Homo sapiens
Compartment: plasma membrane

Set (3 results from a total of 25)

Identifier: R-HSA-204948
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-6783491
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-6785476
Species: Homo sapiens
Compartment: cytosol

Pathway (3 results from a total of 44)

Identifier: R-HSA-448706
Species: Homo sapiens
Compartment: cytosol
The IL-1 family of cytokines that interact with the Type 1 IL-1R include IL-1α (IL1A), IL-1β (IL1B) and the IL-1 receptor antagonist protein (IL1RAP). IL1RAP is synthesized with a signal peptide and secreted as a mature protein via the classical secretory pathway. IL1A and IL1B are synthesised as cytoplasmic precursors (pro-IL1A and pro-IL1B) in activated cells. They have no signal sequence, precluding secretion via the classical ER-Golgi route (Rubartelli et al. 1990). Processing of pro-IL1B to the active form requires caspase-1 (Thornberry et al. 1992), which is itself activated by a molecular scaffold termed the inflammasome (Martinon et al. 2002). Processing and release of IL1B are thought to be closely linked, because mature IL1B is only seen inside inflammatory cells just prior to release (Brough et al. 2003). It has been reported that in monocytes a fraction of cellular IL1B is released by the regulated secretion of late endosomes and early lysosomes, and that this may represent a cellular compartment where caspase-1 processing of pro-IL1B takes place (Andrei et al. 1999). Shedding of microvesicles from the plasma membrane has also been proposed as a mechanism of secretion (MacKenzie et al. 2001). These proposals superceded previous models in which non-specific release due to cell lysis and passage through a plasma membrane pore were considered. However, there is evidence in the literature that supports all of these mechanisms and there is still controversy over how IL1B exits from cells (Brough & Rothwell 2007). A calpain-like potease has been reported to be important for the processing of pro-IL1A, but much less is known about how IL1A is released from cells and what specific roles it plays in biology.
Identifier: R-HSA-69416
Species: Homo sapiens
Procaspase-8 monomers undergo dimerization. The dimerization event occurs at death-inducing signaling complex (DISC) and results in a reposition of the procaspase-8 inter-subunit linker to become accessible for intermolecular processing by the associated procaspase-8 molecule [Keller N et al 2010; Oberst A et al 2010].
Identifier: R-HSA-9648002
Species: Homo sapiens
RAS proteins undergo several processing steps during maturation including farnesylation, carboxy-terminal cleavage and carboxymethylation, among others. These steps are required for their membrane localization and function and ultimately for their ability to activate RAF (reviewed in Gysin et al, 2011; Ahearn et al, 2018).

ChemicalDrug (1 results from a total of 1)

Identifier: R-ALL-9729895
Compartment: nucleoplasm

Chemical Compound (2 results from a total of 2)

Identifier: R-ALL-446596
Compartment: extracellular region
Primary external reference: ChEBI: procainamide: 8428
Identifier: R-ALL-446598
Compartment: cytosol
Primary external reference: ChEBI: procainamide: 8428

OtherEntity (2 results from a total of 2)

Identifier: R-ALL-5694171
Compartment: endoplasmic reticulum membrane
Identifier: R-ALL-113717
Compartment: nucleoplasm

Icon (3 results from a total of 4)

Species: Homo sapiens
Curator: Steve Jupe
Designer: Cristoffer Sevilla
Procollagen icon
Pro collagen
Designer: Cristoffer Sevilla
No process arrow icon
An arrow that represents that a single or multiple processes are not happening due to a disease related process
Designer: Cristoffer Sevilla
Process arrow icon
An arrow that represents a single or a multiple processes of one or more elements
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