Search results for PTGES2

Showing 5 results out of 5

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Species

Types

Compartments

Search properties

Protein (3 results from a total of 3)

Identifier: R-HSA-6799232
Species: Homo sapiens
Compartment: azurophil granule lumen
Primary external reference: UniProt: PTGES2: Q9H7Z7
Identifier: R-HSA-6806185
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: Q9H7Z7
Identifier: R-HSA-5423596
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: PTGES2: Q9H7Z7

Set (1 results from a total of 1)

Identifier: R-HSA-8864254
Species: Homo sapiens
Compartment: cytosol

Reaction (1 results from a total of 1)

Identifier: R-HSA-265295
Species: Homo sapiens
Compartment: cytosol
Prostaglandin E2 (PGE2) is the most abundant prostanoid in the body and is a major mediator of inflammation in diseases such as osteoarthritis and rheumatoid arthritis. The product of arachidonic acid, prostaglandin H2 (PGH2) serves as the substrate for the isomerization to PGE2. The conversion is carried out by prostaglandin E synthases. Of the three forms, two are predominanly cytosolic. Prostaglandin E synthase 3 (PTGES3) is also called cytosolic prostaglandin E2 synthase (cPGES). Prostaglandin E synthase 2 (mPGES-2, PTGES2) is synthesized as a Golgi membrane-associated protein which undergoes a spontaneous cleavage of the N-terminal hydrophobic domain leading to a truncated mature cytosolic protein.
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