Search results for PYCR1

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Species

Types

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Reaction types

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Protein (1 results from a total of 1)

Identifier: R-HSA-70656
Species: Homo sapiens
Compartment: mitochondrial matrix
Primary external reference: UniProt: PYCR1: P32322

Complex (1 results from a total of 1)

Identifier: R-HSA-70662
Species: Homo sapiens
Compartment: mitochondrial matrix

Reaction (3 results from a total of 3)

Identifier: R-HSA-70664
Species: Homo sapiens
Compartment: mitochondrial matrix
Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the reaction of (S)-1-pyrroline-5-carboxylate with NADH + H+ to form proline and NAD+ (De Ingeniis et al. 2012). The active enzyme is a homodecamer (Meng et al. 2006). Subcellular fractionation (De Ingeniis et al. 2012) and co-localization studies (Reversade et al. 2009) indicate that PYCR1 is mitochondrial. Its deficiency is associated with cutis laxa (Reversade et al. 2009).
Identifier: R-HSA-6783939
Species: Homo sapiens
Compartment: mitochondrial matrix
Pyrroline-5-carboxylate reductase 2 (PYCR2) catalyzes the reaction of (S)-1-pyrroline-5-carboxylate with NADH + H+ to form proline and NAD+ (De Ingeniis et al. 2012). The active enzyme is inferred to be a homodecamer by virtue of its similarity to PYCR1 (Meng et al. 2006). Subcellular fractionation (De Ingeniis et al. 2012) and co-localization studies (Nakayama et al. 2015) indicate that PYCR1 is mitochondrial. Its deficiency is associated with microcephaly and hypomyelination (Nakayama et al. 2015).
Identifier: R-HSA-6783955
Species: Homo sapiens
Compartment: cytosol
Pyrroline-5-carboxylate reductase-like (PYCRL) catalyzes the reaction of (S)-1-pyrroline-5-carboxylate with NADPH + H+ to form proline and NADP+ in the cytosol (De Ingeniis et al. 2012). While the pyrroline-5-carboxylate reductase described by Merrill et al. (1989) is taken to be the PYCR1 or PYCR2 gene product, its abundance in red blood cell cytosol and its strong preference for NADP as a cofactor suggest the alternative interpretation that it is the product of PYCRL.
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