Search results for RAB21

Showing 9 results out of 9

×

Species

Types

Compartments

Search properties

Species

Types

Compartments

Search properties

Protein (3 results from a total of 3)

Identifier: R-HSA-8873687
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: RAB21: Q9UL25
Identifier: R-HSA-8876830
Species: Homo sapiens
Compartment: early endosome membrane
Primary external reference: UniProt: RAB21: Q9UL25
Identifier: R-HSA-8873769
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: Q9UL25

Set (1 results from a total of 1)

Identifier: R-HSA-8933368
Species: Homo sapiens
Compartment: cytosol

Reaction (2 results from a total of 2)

Identifier: R-HSA-8876837
Species: Homo sapiens
Compartment: early endosome membrane, cytosol
RAB21 is involved in the endocytosis of transferrin and EGF receptors as well as of integrins, and RAB21-mediated integrin trafficking is required for cytokinesis (Simpson et al, 2004; Pellinen et al, 2006; Pellinen et al, 2008; reviewed in Miserey-Lenkei and Colombo, 2016). In addition, RAB21 contributes to neurite and dendrite outgrowth, macrophage outgrowth and fusion of autophagosomes with lysosomes (Obayashi et al, 2012; Burgo et al, 2009; Burgo et al, 2012; Jean et al, 2012; Jean et al, 2015). RAB21 nucleotide exchange is stimulated by ANKRD27, also known as VARP (VPS9 ankyrin repeat protein), which in addition to promoting RAB21 guanyl-nucleotide exchange, also interacts with numerous RAB effectors and contributes to multiple steps of endosomal trafficking (Zhang et al, 2006; Obayashi et al, 2012; reviwed in Fukuda, 2016; Ishida et al, 2016). Other GEFs for RAB21 include the myotubularin proteins SBF1 and SBF2 (also known as MTMR5 and MTMR13) which contribute to macrophage outgrowth and fusion of autophagosomes with lysosomes (Jean et al, 2012; Jean et al, 2015). Interaction of RAB21:GDP with its GEFs promotes release of GDP, allowing GTP to bind, and precludes the interaction of RAB21 with GDI and CHM proteins.
Identifier: R-HSA-8877760
Species: Homo sapiens
Compartment: melanosome membrane, cytosol
RAB32 and RAB38 play non-redundant but overlapping roles in melanosome and lysosome-related organelle (LRO) biogenesis (Loftus et al, 2002; Wasmeier et al, 2006; Lopes et al, 2007; Wang et al, 2008; Bultema et al, 2012; reviewed in Bultema and di Pietro, 2012). Through interaction with effector protein ANKRD27 (also known as VARP, a RAB21-specific GEF), RAB32 and RAB38 control trafficking of melanogenic enzymes; ANKRD27 GEF activity does not appear to be essential for this, however (Tamura et al, 2009; Tamura et al, 2011; Ohbayahsi et al, 2012). BLOC-3, a dimeric complex of HPS1 and HPS4, has RAB32- and RAB38 GEF activity and mutation in the genes encoding HPS1 and HPS4 results in defects in pigmentation and mislocalization of RAB32 and 38, and are associated with the rare autosomal recessive disorder Hermansky-Pudlak Syndrome (Gerondopoulos et al, 2012; reviewed in Ishida et al, 2016). Interaction of RAB32:GDP or RAB38:GDP with BLOC-3 promotes release of GDP, allowing GTP to bind, and precludes the interaction of the RAB proteins with GDI and CHM proteins.

Complex (3 results from a total of 3)

Identifier: R-HSA-8876836
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-8876839
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-8876838
Species: Homo sapiens
Compartment: early endosome membrane
Cite Us!