Search results for RAB27B

Showing 9 results out of 9

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Species

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Species

Types

Compartments

Reaction types

Search properties

Protein (5 results from a total of 5)

Identifier: R-HSA-8862955
Species: Homo sapiens
Compartment: platelet dense granule membrane
Primary external reference: UniProt: RAB27B: O00194
Identifier: R-HSA-8873706
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: RAB27B: O00194
Identifier: R-HSA-8862952
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: O00194
Identifier: R-HSA-8877280
Species: Homo sapiens
Compartment: melanosome membrane
Primary external reference: UniProt: RAB27B: O00194
Identifier: R-HSA-8873786
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: O00194

Set (1 results from a total of 1)

Identifier: R-HSA-481030
Species: Homo sapiens
Compartment: extracellular region

Complex (2 results from a total of 2)

Identifier: R-HSA-8877294
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-8877288
Species: Homo sapiens
Compartment: melanosome membrane

Reaction (1 results from a total of 1)

Identifier: R-HSA-8877308
Species: Homo sapiens
Compartment: melanosome membrane, cytosol
Vertebrate RAB27 exists in two isoforms, RAB27A and RAB27B, with overlapping but distinct functions in trafficking to melanosomes, secretory granules and platelets (Kondo et al, 2006; Figueiredo et al, 2008; Tarafder et al, 2011; reviewed in Fukuda et al, 2013). Studies in nematodes and vertebrates have identified MADD as a RAB27 GEF required for its activity (Mahoney et al, 2006; Tarafder et al, 2011; Yoshimura et al, 2010). Interaction of RAB27:GDP with its GEFs promotes release of GDP, allowing GTP to bind, and precludes the interaction of RAB27 with GDI and CHM proteins.
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