Large scale screens have identified numerous RAB proteins that interact with components of the COG complex (Fukuda et al, 2008; Miller et al, 2013; reviewed in Willet et al, 2013). Although RAB proteins are known to play key roles in trafficking and Golgi structure and function, the significance of some of these interactions is not yet clear (Kelly et al, 2012; Liu et al, 2013; reviewed in Liu and Storrie, 2015).