Search results for RAB31

Showing 11 results out of 11

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Protein (5 results from a total of 5)

Identifier: R-HSA-6804797
Species: Homo sapiens
Compartment: secretory granule membrane
Primary external reference: UniProt: RAB31: Q13636
Identifier: R-HSA-8873690
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: RAB31: Q13636
Identifier: R-HSA-6804813
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: Q13636
Identifier: R-HSA-8877278
Species: Homo sapiens
Compartment: early endosome membrane
Primary external reference: UniProt: RAB31: Q13636
Identifier: R-HSA-8873974
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: Q13636

Set (1 results from a total of 1)

Identifier: R-HSA-8877299
Species: Homo sapiens
Compartment: cytosol

Reaction (2 results from a total of 2)

Identifier: R-HSA-8877311
Species: Homo sapiens
Compartment: early endosome membrane, cytosol
RAB31, also referred to as RAB22B, is a member of the RAB5 family of proteins (Chen et al, 1996; Bao et al, 2002). It is involved in trafficking pathways at the trans-Golgi network (TGN) and early endosome, where it is required for insulin-stimulated GLUT4 transport, internalization of the EGFR receptor and for mannose-6-phosphate receptor transport from the TGN (Rodriguez-Gabin et al, 2001; Lodhi et al, 2007; Chua et al, 2014; Ng et al, 2007; Ng et al, 2009; Rodriguez-Gabin et al, 2009). RAB31 overexpression is also implicated in cellular proliferation and apoptosis during cancer progression (Pan et al, 2015; reviewed in Chua and Tang, 2015). RAB31 is activated by VPS domain-containing GEFs GAPVD1 (also known as GAPEX5 or RAP6) and RIN3 (Hunker et al, 2006; Lodhi et al, 2007; Kajiho et al, 2003; Kajiho et al, 2011). Interaction of RAB31:GDP with its GEFs promotes release of GDP, allowing GTP to bind, and precludes the interaction of RAB31 with GDI and CHM proteins.
Identifier: R-HSA-8875320
Species: Homo sapiens
Compartment: early endosome membrane, cytosol
RAB5 has roles at early endosomal compartments including fusion of vesicles originating from the plasma membrane with early endosomes, and is implicated in clathrin-mediated endocytosis (Chavrier et al, 1990; Bucci et al, 1992; Gorvel et al, 1991; Hoffenberg et al, 2000; Zeigerer et al, 2012; Taylor et al, 2011). RAB5 activation is mediated by a number of GEFs including members of the RIN (RAS and RAB interactor) and ALS2 families and GAPVD1, all of which belong to the VPS9-domain containing group (Horiuchi et al, 1997; Tall et al, 2001; Saito et al, 2002; Kajiho et al, 2003; Kajiho et al, 2011; Kunita et al, 2004; Hadano et al, 2004; Hunker et al, 2006; Suzuki-Utsunomiya et al, 2007; reviewed in Ishida et al, 2016). Interaction of RAB5 with its GEFs promotes release of GDP, allowing GTP to bind, and precludes the interaction of RAB5 with GDI and CHM proteins.

Complex (3 results from a total of 3)

Identifier: R-HSA-8877287
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-8877285
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-8877284
Species: Homo sapiens
Compartment: early endosome membrane
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