Mtb phosphatidylinositol-3-phosphatase (SapM) blocks autophagosome-lysosome fusion in macrophages by binding to the human ras related protein Rab-7a (RAB7) (Hu et.al 2015).

Ras-related protein with guanosine 5'-triphosphates bound to GTP (RAB5A:GTP,RAB7A:GTP) get deactivated through dephosphorylation of GTP via the GTPase-activating protein (GAP)-like activity of the Mtb nucleoside diphosphate kinase (ndkA) (Chopra et al. 2004, Sun et al. 2010).

Active GTP bound RHOD binds to the following effectors at the plasma membrane:
DIAPH1 (Kyrkou et al. 2013)
PAK6 (Durkin et al. 2017)

The following candidate RHOD effectors that can localize to plasma membrane and cytosol were reported in the high throughput screen by Bagci et al. 2020:
ACTN1 (Bagci et al. 2020)
ADD3 (Bagci et al. 2020)
AKAP12 (Bagci et al. 2020)
ARHGAP1 (Bagci et al. 2020)
ARHGAP39 (Bagci et al. 2020)
CAPZB (Bagci et al. 2020)
CAV1 (Bagci et al. 2020)
CPNE8 (Bagci et al. 2020)
DBN1 (Bagci et al. 2020)
DIAPH3 (Bagci et al. 2020)
EFHD2 (Bagci et al. 2020)
ESYT1 (Bagci et al. 2020)
LMNB1 (Bagci et al. 2020)
MCAM (Bagci et al. 2020)
RAB7A (Bagci et al. 2020)
SLC4A7 (Bagci et al. 2020)
STBD1 (Bagci et al. 2020)
STEAP3 (Bagci et al. 2020)
TMPO (Bagci et al. 2020)
TOR1AIP1 (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)

The following putative effectors do not bind to active RHOD:
ACTB (Bagci et al. 2020)
BASP1 (Bagci et al. 2020)
FAM169A (Bagci et al. 2020)
MTMR1 (Bagci et al. 2020)
POTEE (Bagci et al. 2020)
SENP1 (Bagci et al. 2020)
SNAP23 (Bagci et al. 2020)
SOWAHC (Bagci et al. 2020)

Active GTP bound RHOF binds the following effectors:
BAIAP2L1 (Sudhaharan et al. 2016)
BAIAP2L2 (Sudhaharan et al. 2016)
DIAPH1 (Fan et al. 2010)
DIAPH2 (Gorelik et al. 2011)
FARP1 (Fan et al. 2015)

The following candidate RHOF effectors that can localize to cytosol or the plasma membrane were reported by Bagci et al. 2020 to bind active RHOF:
ACTB (Bagci et al. 2020)
ACTN1 (Bagci et al. 2020)
ADD3 (Bagci et al. 2020)
AKAP12 (Bagci et al. 2020)
ARHGAP1 (Bagci et al. 2020)
ARHGAP39 (Bagci et al. 2020)
BASP1 (Bagci et al. 2020)
CAPZB (Bagci et al. 2020)
CAV1 (Bagci et al. 2020)
CPNE8 (Bagci et al. 2020)
DIAPH3 (Bagci et al. 2020)
ESYT1 (Bagci et al. 2020)
FAM169A (Bagci et al. 2020)
LMNB1 (Bagci et al. 2020)
MCAM (Bagci et al. 2020)
MTMR1 (Bagci et al. 2020)
POTEE (Bagci et al. 2020)
RAB7A (Bagci et al. 2020)
SENP1 (Bagci et al. 2020)
SLC4A7 (Bagci et al. 2020)
SNAP23 (Bagci et al. 2020)
SOWAHC (Bagci et al. 2020)
STEAP3 (Bagci et al. 2020)
TMPO (Bagci et al. 2020)
TOR1AIP1 (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)

Several putative effectors that localize to endoplasmic reticulum, endosomes or the mitochondrial outer membrane were reported to bind active RHOF by Bagci et al. 2020, but as the localization of RHOF to these cellular compartments has not been established, these effectors have not been annotated:
EMD
LBR
LEMD3
LMAN1
PGRMC2
VRK2

The following putative effectors were reported not to bind active RHOF:
DBN1 (Bagci et al. 2020)
EFHD2 (Bagci et al. 2020)
GOLGA8R (Bagci et al. 2020)
HINT2 (Bagci et al. 2020)
MOSPD2 (Bagci et al. 2020)
STBD1 (Bagci et al. 2020)
VAPB (Bagci et al. 2020)

RHOH plays an important role in development of T lymphocytes and binds to several kinases involved in T lymphocyte activation, including:
ZAP70 (Gu et al. 2006, Chae et al. 2010, Wang et al. 2011)
LCK (Chae et al. 2010, Wang et al. 2011)
CSK (Wang et al. 2010).

Additional RHOH interactors include:
PAK1 (Wang et al. 2010; Tajadura Ortega et al. 2018)
PAK2 (Tajadura Ortega et al. 2018)
PAK4 (Tajadura Ortega et al. 2018)
PAK5 (Wu and Frost 2006; Tajadura Ortega et al. 2018)
PAK6 (Tajadura Ortega et al. 2018)

The following RHOH interactors have only been reported in a high throughput screen by Bagci et al. 2020, and are therefore annotated as candidate RHOH effectors:
CAV1 (Bagci et al. 2020).
DBN1 (Bagci et al. 2020)
DBT (Bagci et al. 2020)
FAM91A1 (Bagci et al. 2020)
JUP (Bagci et al. 2020)
LAMTOR1 (Bagci et al. 2020)
MTR (Bagci et al. 2020)
NIPSNAP2 (Bagci et al. 2020)
NSFL1C (Bagci et al. 2020)
OSBPL11 (Bagci et al. 2020)
RAB7A (Bagci et al. 2020)
RALGAPA1 (Bagci et al. 2020)
ROCK1 (Bagci et al. 2020)
ROCK2 (Bagci et al. 2020)
SLC1A5 (Bagci et al. 2020)
SLC4A7 (Bagci et al. 2020)
STOM (Bagci et al. 2020)
TFRC (Bagci et al. 2020)
TMEM59 (Bagci et al. 2020)
TUBA1B (Bagci et al. 2020)
UACA (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
VCP (Bagci et al. 2020)
WDR11 (Bagci et al. 2020)

Active GTP bound RHOJ binds the following effectors:
FMNL3 (Richards et al. 2015)
PAK1 (Vignal et al. 2000, Ho et al. 2012; Bagci et al. 2020)
PAK3 (Sundararaman et al. 2020)
WIP2 WASP complex, through direct interaction with WAS (WASP) (Vignal et al. 2000), WASL (Abe et al. 2003, Bagci et al. 2020) and WIPF2 (Bagci et al. 2020)

The following RHOJ effectors are annotated as candidates because the knowledge on their relationship with RHOJ is limited:
ARHGAP1 (Bagci et al. 2020)
ARHGEF7 (Bagci et al. 2020)
ARL13B (Bagci et al. 2020)
CAV1 (Bagci et al. 2020)
CDC42 (Bagci et al. 2020)
CDC42BPA (Bagci et al. 2020)
CDC42BPB (Bagci et al. 2020)
CDC42EP1 (Bagci et al. 2020)
CPNE8 (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
DIAPH3 (Bagci et al. 2020)
FNBP1 (Bagci et al. 2020)
FNBP1L (Bagci et al. 2020)
GIT1 (Bagci et al. 2020)
GIT2 (Bagci et al. 2020)
GJA1 (Bagci et al. 2020)
IQGAP3 (Bagci et al. 2020)
JUP (Bagci et al. 2020)
LAMTOR1 (Bagci et al. 2020)
MPP7 (Bagci et al. 2020)
NIPSNAP2 (Bagci et al. 2020)
PAK2 (Bagci et al. 2020)
PAK4 (Bagci et al. 2020)
RAB7A (Bagci et al. 2020)
SCRIB (Bagci et al. 2020)
SLC1A5 (Bagci et al. 2020)
SLC4A7 (Bagci et al. 2020)
SNAP23 (Bagci et al. 2020)
STEAP3 (Bagci et al. 2020)
STOM (Bagci et al. 2020)
TFRC (Bagci et al. 2020)
TMPO (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
WWP2 (Bagci et al. 2020)

In the screen by Bagci et al. 2020, active RHOJ was found to interact with LBR and YKT6, two proteins that localize to the endoplasmic reticulum membrane. However, since RHOJ localization at the endoplasmic reticulum membrane has not been reported, these two interactions have not been annotated.

RHOJ does not interact with the following RHO GTPase effectors:
ARFGAP2 (Bagci et al. 2020)
ARFGAP3 (Bagci et al. 2020)
CDC42EP2 (Bagci et al. 2020)
CDC42EP4 (Bagci et al. 2020)
CDC42SE2 (Bagci et al. 2020)
FMNL1 (Bagci et al. 2020)
FMNL2 (Bagci et al. 2020)
GFOD1 (Bagci et al. 2020)
GOLGA8R (Bagci et al. 2020)
KCTD3 (Bagci et al. 2020)
KIAA0355 (Bagci et al. 2020)
PLEKHG3 (Bagci et al. 2020)
ROCK1 (Bagci et al. 2020)
ROCK2 (Bagci et al. 2020)
SH3PXD2A (Bagci et al. 2020)
SHKBP1 (Bagci et al. 2020)
SLK (Bagci et al. 2020)
WDR81 (Bagci et al. 2020)
WDR91 (Bagci et al. 2020)
WIPF1 (Bagci et al. 2020)
WIPF3 (Bagci et al. 2020)

In its GTP bound active form, plasma membrane associated RAC2 binds to the following effectors:
IQGAP1 (Meng et al. 2007)
KIAA0355 (Bagci et al. 2020: interaction tested in detail)
PAK1 (Knaus et al. 1998; Hoppe and Swanson 2004; Carstanjen et al. 2005)
PAK4 (Zhang et al. 2019; Bagci et al. 2020)
PI3K alpha (Bokoch et al. 1996)
PLD2 (Peng et al. 2011)

The following candidate RAC2 effectors have so far only been reported in the high throughput screen by Bagci et al. 2020:
ABI1 (Bagci et al. 2020)
ABI2 (Bagci et al. 2020)
BAIAP2L1 (Bagci et al. 2020)
CAV1 (Bagci et al. 2020)
CDC42 (Bagci et al. 2020)
CDC42EP1 (Bagci et al. 2020)
CDC42EP4 (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
DIAPH3 (Bagci et al. 2020)
DSG2 (Bagci et al. 2020)
EPHA2 (Bagci et al. 2020)
ERBIN (Bagci et al. 2020)
GIT1 (Bagci et al. 2020)
GIT2 (Bagci et al. 2020)
ITGB1 (Bagci et al. 2020)
LAMTOR1 (Bagci et al. 2020)
MCAM (Bagci et al. 2020)
MPP7 (Bagci et al. 2020)
NCKAP1 (Bagci et al. 2020)
NHS (Bagci et al. 2020)
PAK2 (Bagci et al. 2020)
RAB7A (Bagci et al. 2020)
SLITRK5 (Bagci et al. 2020)
STBD1 (Bagci et al. 2020)
STX5 (Bagci et al. 2020)
SWAP70 (Bagci et al. 2020)
TAOK3 (Bagci et al. 2020)
TFRC (Bagci et al. 2020)
TMPO (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
WAVE2 regulatory complex (interacts with subunits CYFIP1 and WASF2) (Bagci et al. 2020)

RAC2 does not bind the following RHO GTPase effectors:
ABL2 (Bagci et al. 2020)
AMIGO2 (Bagci et al. 2020)
ARAP2 (Bagci et al. 2020)
ARFGAP3 (Bagci et al. 2020)
BAIAP2 (Bagci et al. 2020)
BRK1 (Bagci et al. 2020)
DOCK1 (Bagci et al. 2020)
DOCK5 (Bagci et al. 2020)
ELMO2 (Bagci et al. 2020)
FERMT2 (Bagci et al. 2020)
HSPE1 (Bagci et al. 2020)
IL32 (Bagci et al. 2020)
JAG1 (Bagci et al. 2020)
LETM1 (Bagci et al. 2020)
NDUFA5 (Bagci et al. 2020)
NDUFS3 (Bagci et al. 2020)
PLEKHG3 (Bagci et al. 2020)
PLEKHG4 (Bagci et al. 2020)
RAPGEF1 (Bagci et al. 2020)
SHMT2 (Bagci et al. 2020)
SLC1A5 (Bagci et al. 2020)
SLITRK3 (Bagci et al. 2020)
SNAP23 (Bagci et al. 2020)
WAVE1 complex subunit WASF1 (Bagci et al. 2020)
YKT6 (Bagci et al. 2020)