Search results for RAC1

Showing 22 results out of 270

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Species

Types

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Species

Types

Compartments

Reaction types

Search properties

Protein (4 results from a total of 10)

Identifier: R-HSA-351141
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: RAC1: P63000
Identifier: R-HSA-442615
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: RAC1: P63000
Identifier: R-HSA-5672076
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: RAC1: P63000
Identifier: R-HSA-6804770
Species: Homo sapiens
Compartment: secretory granule membrane
Primary external reference: UniProt: RAC1: P63000

Interactor (1 results from a total of 1)

Identifier: P63000-1
Species: Homo sapiens
Primary external reference: UniProt: P63000-1

Reaction (4 results from a total of 156)

Identifier: R-HSA-9013143
Species: Homo sapiens
Compartment: plasma membrane, cytosol
The following guanine nucleotide exchange factors (GEFs) were shown to bind RAC1 and catalyze GDP to GTP exchange on RAC1, resulting in formation of the active RAC1:GTP complex (the high throughput study by Bagci et al. examined binding of GEFs to inactive RAC1 mutant without testing for RAC1-directed GEF activity and is cited as supporting evidence):
DOCK3 (Namekata et al. 2004, Yang et al. 2012, Namekata et al. 2012; Müller et al. 2020)
FGD5 (Müller et al. 2020)
GNA13 (Radhika et al. 2004)
PLEKHG6 (Müller et al. 2020)
PREX1 (Yoshizawa et al. 2005; Dong et al. 2005; Marei et al. 2016; Jaiswal et al. 2013; Müller et al. 2020)
PREX2 (Joseph and Norris 2005; Müller et al. 2020)
RASGRF2 (Schwechter et al. 2013; Müller et al. 2020)
SWAP70 (Shinohara et al. 2002; Gupta et al. 2003; Baranov et al. 2016; Bagci et al. 2020: binding to inactive RAC1)
TIAM2 (Matsuo et al. 2002; Müller et al. 2020)
TRIO (Debant et al. 1996; Moshfegh et al. 2014; Peurois et al. 2017; Jaiswal et al. 2013: RAC1-directed GEF acivity of the N-terminal GEF1 domain of TRIO; Müller et al. 2020: RAC1-directed GEF activity of the full-length TRIO; Bagci et al. 2020: binding of full-length TRIO to inactive RAC1)
VAV1 (Teramoto et al. 1997; Heo et al. 2005; Aghazadeh et al. 2000; Crespo et al. 1997; Müller et al. 2020)
VAV2 (Itoh et al. 2008; Aoki et al. 2005; Heo et al. 2005; Jaiswal et al. 2013; Müller et al. 2020; Bagci et al. 2020: binding to inactive RAC1)


The following GEFs were shown to bind and activate RAC1 in some but not all studies and are annotated as candidate RAC1 GEFs (or were shown, in the high throughput screen by Bagci et al. 2020, to bind to nucleotide free RAC1 mutant, as indicated):
ABR (Chuang et al. 1995: RAC1-directed GEF activity; Müller et al. 2020: no RAC1 directed GEF activity)
ALS2 (Topp et al. 2004, Kanekura et al. 2005, Topp et al. 2005: RAC1 directed GEF activity; Müller et al. 2020: no RAC1 directed GEF activity)
ARHGEF4 (Itoh et al. 2008: RAC1 directed GEF activity; Anderson and Hamann 2012, Gotthardt and Ahmadian 2007, Jaiswal et al. 2013, Müller et al. 2020: no RAC1 directed GEF activity)
ARHGEF5 (Xie et al. 2005: RAC1 directed GEF activity; Wang et al. 2009, Müller et al. 2020: no RAC1 directed GEF activity; Bagci et al. 2020: no binding to inactive RAC1)
ARHGEF6 (Manser et al. 1998, Ramakers et al. 2012: RAC1 directed GEF activity; Müller et al. 2020: no RAC1 directed GEF activity)
ARHGEF7 (Ten Klooster et al. 2006, Manser et al. 1998: RAC1 directed GEF activity; Bagci et al. 2020: binding to inactive RAC1; Müller et al. 2020: no RAC1 directed GEF activity)
ARHGEF10 (Müller et al. 2020: RAC1 directed GEF activity; Mohl et al. 2006: no RAC1 directed GEF activity)
ARHGEF11 (Bagci et al. 2020: binding to inactive RAC1; Rümenapp et al. 1999; Jaiswal et al. 2011; Jaiswal et al. 2013; Müller et al. 2020: no RAC1 directed GEF activity:)
ARHGEF15 (Fukushima et al. 2016: RAC1 directed GEF activity; Müller et al. 2020: no RAC1 directed GEF activity)
ARHGEF18 (Niu et al. 2003: RAC1 directed GEF activity; Blomquist et al. 2000, Müller et al. 2020: no RAC1 directed GEF activity)
ARHGEF19 (Wang et al. 2004: RAC1 directed GEF activity; Müller et al. 2020: no RAC1 directed GEF activity)
ARHGEF25 (Guo et al. 2003: RAC1 directed GEF activity; Müller et al. 2020: no RAC1 directed GEF activity)
ARHGEF39 (Zhou et al. 2018: RAC1 directed GEF activity; Müller et al. 2020: no RAC1 directed GEF activity)
BCR (Chuang et al. 1995: RAC1 directed GEF activity; Bagci et al. 2020 binding to inactive RAC1; Korus et al. 2002, Müller et al. 2020: no RAC1 directed GEF activity)
DEF6 (Mavrakis et al. 2004: activation of RAC1, GEF activity of DEF6 has not been examined in vitro)
DOCK1 (Cote and Vuori 2002, Li et al. 2003: RAC1 directed GEF activity; Bagci et al. 2020: binding to inactive RAC1; Müller et al. 2020: no RAC1 directed GEF activity)
DOCK2 (Kulkarni et al. 2011: RAC1 directed GEF activity; Müller et al. 2020: no RAC1 directed GEF activity)
DOCK4 (Abraham et al. 2015: RAC1-directed GEF activity; Müller et al. 2020: no RAC1 directed GEF activity)
DOCK5 (Omi et al. 2008, Vives et al. 2011, Ferrandez et al. 2017: RAC1 directed GEF activity; Bagci et al. 2020: binding to inactive RAC1; Müller et al. 2020: no RAC1 directed GEF activity)
DOCK6 (Miyamoto et al. 2007: RAC1 directed GEF activity; Bagci et al. 2020: binding to inactive RAC1; Müller et al. 2020: no RAC1 directed GEF activity)
DOCK7 (Kukimoto Niino et al. 2019, Yamauchi et al. 2008, Majewski et al. 2012, Zhou et al. 2013: RAC1 directed GEF activity; Bagci et al. 2020: binding to inactive RAC1; Müller et al. 2020: no RAC1 directed GEF activity)
DOCK8 (Wang et al. 2015: RAC1 directed GEF activity; Bagci et al. 2020: no binding to inactive RAC1; Müller et al. 2020: no RAC1 directed GEF activity)
DOCK9 (Bagci et al. 2020: binding to inactive RAC1; Kulkarni et al. 2011, Müller et al. 2020: no RAC1 directed GEF activity)
DOCK10 (Ruiz Lafuente et al. 2015, Müller et al. 2020: RAC1 directed GEF activity; Bagci et al. 2020: no binding to inactive RAC1)
DOCK11 (Bagci et al. 2020: binding to inactive RAC1; Lin et al. 2006, Müller et al. 2020: no RAC1 directed GEF activity)
ECT2 (Tatsumoto et al. 1999: RAC1 directed GEF activity; Müller et al. 2020: no RAC1 directed GEF activity; Bagci et al. 2020: no binding to inactive RAC1)
FARP1 (Cheadle and Biederer 2012: RAC1-directed GEF activity; Bagci et al. 2020: binding to inactive RAC1; Müller et al. 2020: no RAC1 directed GEF activity)
FARP2 (Kubo et al. 2002: RAC1-directed GEF activity; Müller et al. 2020: no RAC1 directed GEF activity)
KALRN (Penzes et al. 2003, Wu et al. 2013: RAC1-directed GEF activity when using the N-terminal GEF1 domain of KALRN; Müller et al. 2020: no RAC1 directed GEF activity when using full-length KALRN)
MCF2 (Jaiswal et al. 2013, Müller et al. 2020: RAC1 directed GEF activity; Reuther et al. 2001: no RAC1 directed GEF activity);
MCF2L (Bagci et al. 2020: binding to inactive RAC1; Whitehead et al. 1999; Jaiswal et al. 2013; Müller et al. 2020: no RAC1 directed GEF activity)
NGEF (Zhang et al. 2007: RAC1 directed GEF activity; Müller et al. 2020: no RAC1 directed GEF activity; Bagci et al. 2020: no binding to inactive RAC1)
PLEKHG1 (Abiko et al. 2015: RAC1 directed GEF activity; Müller et al. 2020: no RAC1 directed GEF activity; Bagci et al. 2020: no binding to inactive RAC1)
PLEKHG2 (Ueda et al. 2008: RAC1 directed GEF activity; Müller et al. 2020: no RAC1 directed GEF activity; Bagci et al. 2020: no binding to inactive RAC1)
PLEKHG3 (Nguyen et al. 2016: RAC1-directed GEF activity; Bagci et al. 2020: binding to inactive RAC1; Müller et al. 2020: no RAC1 directed GEF activity)
PLEKHG4 (Gupta et al. 2013: RAC1 directed GEF activity; Müller et al. 2020: no RAC1 directed GEF activity; Bagci et al. 2020: no binding to inactive RAC1)
SOS1 (Nimnual et al. 1998: RAC1 directed GEF activity; Itoh et al. 2008, Müller et al. 2020: no RAC1 directed GEF activity)
SOS2 (Nimnual et al. 1998: RAC1 directed GEF activity; Itoh et al. 2008, Müller et al. 2020: no RAC1 directed GEF activity)
SPATA13 (Kawasaki et al. 2007, Bristow et al. 2009: RAC1 directed GEF activity; Hamann et al. 2007, Müller et al. 2020: no RAC1 directed GEF activity)
TIAM1 (Itoh et al. 2008, Michiels et al. 1995, Haeusler et al. 2003, Jaiswal et al. 2013, Müller et al. 2020: RAC1 directed GEF activity; Bagci et al. 2020: no binding to inactive RAC1)
VAV3 (Movilla and Bustello 1999, Sachdev et al. 2002, Aoki et al. 2005: RAC1-directed GEF activity; Müller et al. 2020: no RAC1 directed GEF activity)

The following GEFs do not act on RAC1 or were shown to not bind to nucleotide-free RAC1 in the study by Bagci et al. 2020, as indicated:
AKAP13 (Zheng et al. 1995; Müller et al. 2020; Bagci et al. 2020: no binding to inactive RAC1)
ARHGEF1 (Hart et al. 1996; Jaiswal et al. 2013; Jaiswal et al. 2011; Müller et al. 2020; Bagci et al. 2020: no binding to inactive RAC1)
ARHGEF2 (Krendel et al. 2002; Müller et al. 2020; Bagci et al. 2020: no binding to inactive RAC1)
ARHGEF3 (Arthur et al. 2002; Müller et al. 2020)
ARHGEF9 (Reid et al. 1999; Jaiswal et al. 2013; Müller et al. 2020)
ARHGEF10L (Winkler et al. 2005; Müller et al. 2020)
ARHGEF12 (Reuther et al. 2001; Jaiswal et al. 2013; Jaiswal et al. 2011; Müller et al. 2020; Bagci et al. 2020: no binding to inactive RAC1)
ARHGEF16 (Hiramoto Yamaki et al. 2010; Müller et al. 2020; Bagci et al. 2020: no binding to inactive RAC1)
ARHGEF17 (Rümenapp et al. 2002; Müller et al. 2020; Bagci et al. 2020: no binding to inactive RAC1)
ARHGEF26 (Ellerbroek et al. 2004; Müller et al. 2020; Bagci et al. 2020: no binding to inactive RAC1)
ARHGEF28 (van Horck et al. 2001; Jaiswal et al. 2013; Jaiswal et al. 2011; Müller et al. 2020)
ARHGEF40 (Curtis et al. 2004; Müller et al. 2020; Bagci et al. 2020: no binding to inactive RAC1)
DNMBP (Jaiswal et al. 2013; Müller et al. 2020; Bagci et al. 2020: no binding to inactive RAC1)
ECT2L (Müller et al. 2020)
FGD1 (Olson et al. 1996; Müller et al. 2020)
FGD2 (Huber et al. 2008; Müller et al. 2020)
FGD3 (Müller et al. 2020)
FGD4 (Umikawa et al. 1999; Müller et al. 2020)
FGD6 (Müller et al. 2020)
ITSN1 (Hussain et al. 2001; Jaiswal et al. 2013; Müller et al. 2020)
ITSN2 (Müller et al. 2020)
MCF2L2 (Müller et al. 2020)
NET1 (Alberts and Treisman 1998; Müller et al. 2020)
OBSCN (Ford Speelman et al. 2009)
PLEKHG4B (Müller et al. 2020)
PLEKHG5 (De Toledo et al. 2004; Müller et al. 2020)
PLEKHG7 (Müller et al. 2020)
RASGRF1 (Müller et al. 2020)
Identifier: R-HSA-418856
Species: Homo sapiens
Compartment: cytosol, plasma membrane
Rho GEF's DOCK180 and Trio directly associate with DCC, activate Rac-1 on DCC stimulation and cause cell spreading.
Identifier: R-HSA-1433415
Species: Homo sapiens
Compartment: cytosol, plasma membrane
Vav1, once activated by PIP3 binding and phosphorylation by Src kinases, stimulates the GDP/GTP exchange activity of Rac. Vav1 is selective for Rac and catalyses exchange of bound GDP for GTP.
Identifier: R-HSA-428522
Species: Homo sapiens
Compartment: cytosol, plasma membrane
Vilse and its human homolog ARHGAP39 bind directly to the intracellular domains of the corresponding ROBO receptors and promote the hydrolysis of GTP bound to RAC1 (Lundstrom et al. 2004, Hu et al. 2005).

Pathway (4 results from a total of 36)

Identifier: R-HSA-428540
Species: Homo sapiens
A low level of RAC1 activity is essential to maintain axon outgrowth. ROBO activation recruits SOS, a dual specificity GEF, to the plasma membrane via Dock homolog NCK (NCK1 or NCK2) to activate RAC1 during midline repulsion.
Identifier: R-HSA-9013149
Species: Homo sapiens
This pathway catalogues RAC1 guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs), GDP dissociation inhibitors (GDIs) and RAC1 effectors (reviewed by Payapilli and Malliri 2018). RAC1 is one of the three best characterized RHO GTPases, the other two being RHOA and CDC42. RAC1 regulates the cytoskeleton and the production of reactive oxygen species (ROS) (Acevedo and Gonzalez-Billault 2018) and is involved in cell adhesion and cell migration (Marei and Malliri 2017). RAC1 is involved in neuronal development (de Curtis et al. 2014). In neurons, RAC1 activity is regulated by synaptic activation and RAC1-mediated changes in actin cytoskeleton are implicated in dendritic spine morphogenesis, which plays a role in memory formation and learning (Tajeda-Simon 2015; Costa et al. 2020). RAC1 is involved in metabolic regulation of pancreatic islet β-cells and in diabetes pathophysiology (Kowluru 2017; Kowluru et al. 2020). RAC1-mediated activation of NOX2 contributes to mitochondrial damage and the development of retinopathy in patients with diabetes (Sahajpal et al. 2019). RAC1 is important for exercise and contraction-stimulated glucose uptake in skeletal muscles (Sylow et al. 2014). RAC1 plays an important role in the maintenance of intestinal barrier integrity under physiological conditions and during tissue repair after resolution of colitis. Toxins of many diarrhea-causing bacteria target RAC1 (Kotelevets and Chastre 2020). RAC1 is important for skin homeostasis and wound healing and is involved in the pathogenesis of psoriasis (Winge and Marinkovich 2019). RAC1 is essential to vascular homeostasis and chronically elevated RAC1 signaling contributes to vascular pathology (Marinkovic et al. 2015). RAC1 hyperactivation, mutation and copy-number gain are frequently observed in solid tumors (Zou et al. 2017; De et al. 2019; De et al. 2020; Cannon et al. 2020; Kotelevets and Chastre 2020).
Identifier: R-HSA-428543
Species: Homo sapiens
Compartment: plasma membrane
Rho family GTPases, including RAC1, RHOA, and CDC42, are ideal candidates to regulate aspects of cytoskeletal dynamics downstream of axon guidance receptors. Biochemical and genetic studies have revealed an important role for CDC42 and RAC1 in ROBO repulsion. ROBO controls the activity of Rho GTPases by interacting with a family of SLIT/ROBO-specific GAPs (SrGAPs) and Vilse/CrossGAP. SrGAPs inactivate CDC42 and Vilse/CrossGAP specifically inactivates RAC1.
It was recently implicated that SRGAP3 may inactivate RAC1 downstream of SLIT1-activated ROBO2, which promotes neurite outgrowth in mammalian dorsal root ganglion (DRG) neurons (Zhang et al. 2014).
Identifier: R-HSA-9032759
Species: Homo sapiens
DOCK3-mediated activation of RAC1 downstream of BDNF-induced signaling by NTRK2 (TRKB) plays a role in axonal growth and regeneration. DOCK3 can be recruited to the plasma membrane to activate RAC1 by binding to NTRK-associated FYN (Namekata et al. 2010). Alternatively, DOCK3 can, upon poorly elucidated RHOG activation by the BDNF:NTRK2 complex, bind to the RHOG:GTP complex and activate RAC1 in an ELMO1-dependent manner (Namekata et al. 2012).

Set (4 results from a total of 11)

Identifier: R-HSA-9013178
Species: Homo sapiens
Compartment: cytosol, plasma membrane
Identifier: R-HSA-9013168
Species: Homo sapiens
Compartment: cytosol, plasma membrane
Identifier: R-HSA-9013175
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-9714459
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane

Complex (4 results from a total of 55)

Identifier: R-HSA-217289
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-442641
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-445010
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-5674631
Species: Homo sapiens
Compartment: plasma membrane

Icon (1 results from a total of 1)

Species: Homo sapiens
Curator: Steve Jupe
Designer: Cristoffer Sevilla
RAC1 icon
Ras-related C3 botulinum toxin substrate 1
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