Search results for RAG2

Showing 6 results out of 6

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Species

Types

Compartments

Reaction types

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Protein (1 results from a total of 1)

Identifier: R-HSA-5692675
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: RAG2: P55895

DNA Sequence (1 results from a total of 1)

Identifier: R-HSA-5692673
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: RAG2 gene: ENSEMBL:ENSG00000175097

Complex (2 results from a total of 2)

Identifier: R-HSA-8865713
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-8865712
Species: Homo sapiens
Compartment: nucleoplasm

Reaction (2 results from a total of 2)

Identifier: R-HSA-8865711
Species: Homo sapiens
Compartment: nucleoplasm
Based on studies in mice, Bromodomain and WD repeat-containing protein 1 (BRWD1) is recruited to the Immunoglobulin kappa (IgK) locus through interaction with histone H3 acetylated at lysine residues K9 and K14 and phosphorylated at serine residue S10. ERK is implicated in histone H3 serine S10 phosphorylation at the IGK locus. BRWD1 enhances the recruitment of the RAG1:RAG2 recombinase complex to the IgK locus and positions it at recombination signal sequences within the IgK locus by proper positioning of the nucleosomes, in order for the V(D)J recombination to occur (Mandal et al. 2015). Please note that the listed amino acid residues in mature histone H3 match nascent histone H3 residues K10, K15 and S11, respectively. Amino acid positions in Reactome annotations of modified residues and Reactome systematic names correspond to positions in the nascent protein UniProt sequence.
Identifier: R-HSA-8865693
Species: Homo sapiens
Compartment: nucleoplasm
Based on a mouse model study of pro-B cells, binding of Signal transducer and activator of transcription 5A and 5B (STAT5A or STAT5B), activated in response to Interleukin-7 (IL7) signaling to the BRWD1 gene promoter, results in the inhibition of Bromodomain and WD repeat-containing protein 1 (BRWD1) transcription. STAT5 binding coincides with the appearance of H3K27me3 marks at the BRWD1 promoter, a marker of repressed chromatin (Mandal et al. 2015). STAT5 is able to recruit the polycomb repressive complex (PRC2) to genes silenced in response to IL7 signaling (Mandal et al. 2011), which may explain the H3K27me3 marks at STAT5-bound BRWD1 promoter.

In pre-B cells, in contrast to pro-B cells, IL7 signaling is downregulated, which induces BRWD1 transcription. BRWD1 enhances the recruitment of the recombinase complex V(D)J recombination-activating protein 1: V(D)J recombination-activating protein 2 (RAG1:RAG2) to the immunoglobulin kappa locus, thus promoting V(D)J recombination - a key event in B lymphopoiesis (Mandal et al. 2015).

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