Search results for RB1

Showing 26 results out of 489

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Protein (5 results from a total of 397)

RB1

Identifier: R-HSA-68642
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: RB1: P06400

RB1

Identifier: R-HSA-9660621
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: RB1: P06400
Identifier: R-HSA-9661377
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: RB1: P06400
Identifier: R-HSA-9662611
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: RB1: P06400
Identifier: R-HSA-9662608
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: RB1: P06400

Set (5 results from a total of 5)

Identifier: R-HSA-9687348
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-9660658
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-9659785
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-187920
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-187963
Species: Homo sapiens
Compartment: nucleoplasm

Complex (5 results from a total of 26)

Identifier: R-HSA-188373
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-8985470
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-NUL-8985476
Species: Mus musculus, Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-9682726
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-9694258
Species: Homo sapiens
Compartment: cytosol
This COVID-19 Complex instance was generated via electronic inference from a curated CoV-1 (Human SARS coronavirus) Reactome instance. In Reactome, inference is the process used to automatically create orthologous Pathways, Reactions and PhysicalEntities from our expertly curated data (https://reactome.org/documentation/inferred-events).

Reaction (5 results from a total of 39)

Identifier: R-HSA-9659820
Species: Homo sapiens
Compartment: cytosol, nucleoplasm
Amino acid residues 860-876 in the C terminal part of RB1 constitute a bipartite nuclear localization signal (NLS), needed for translocation of RB1 from the cytosol to the nucleus. In the absence of the NLS, only a small portion of RB1 translocates to the nucleus, while a large portion of RB1 is retained in the cytosol (Zacksenhaus et al. 1993).
Identifier: R-HSA-9682712
Species: Homo sapiens
Compartment: cytosol
Human SARS coronavirus 1 (SARS-CoV-1) non-structural protein 15 (nsp15) contains the LXCXE/D motif characteristic of proteins that bind to the retinoblastoma protein RB1. Binding to human RB1 increases the endonuclease activity of nsp15 but is not required for it. RB1 bound to nsp15 is retained in the cytosol. Interaction of nsp15 with RB1 likely affects the cell cycle of infected cells and probably modulates cytotoxicity of SARS-CoV-1 (Bhardwaj et al. 2012).
Identifier: R-HSA-8985460
Species: Homo sapiens
Compartment: nucleoplasm
RUNX2 forms a complex with the tumor suppressor RB1. The C-terminus and B-pocket of RB1 are needed for the interaction (Thomas et al. 2001).
Identifier: R-NUL-8985474
Species: Mus musculus, Homo sapiens
Compartment: nucleoplasm
Recombinant mouse Runx2 (Cbfa1) binds to recombinant human RB1 protein. Endogenous mouse Runx2 and Rb1 also form a complex (Thomas et al. 2001).
Identifier: R-HSA-9694390
Species: Homo sapiens
Compartment: cytosol
This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

Human SARS coronavirus 1 (SARS-CoV-1) non-structural protein 15 (nsp15) contains the LXCXE/D motif characteristic of proteins that bind to the retinoblastoma protein RB1. Binding to human RB1 increases the endonuclease activity of nsp15 but is not required for it. RB1 bound to nsp15 is retained in the cytosol. Interaction of nsp15 with RB1 likely affects the cell cycle of infected cells and probably modulates cytotoxicity of SARS-CoV-1 (Bhardwaj et al. 2012).

Pathway (5 results from a total of 21)

Identifier: R-HSA-9661070
Species: Homo sapiens
Compartment: cytosol
This pathway describes impaired nuclear localization of RB1 mutants that lack the nuclear localization signal (NLS) (Zacksenhaus et al. 1993, Bremner et al. 1997).
Identifier: R-HSA-9661069
Species: Homo sapiens
Compartment: nucleoplasm
This pathway describes impaired binding of RB1 pocket domain mutants to activating E2Fs, E2F1, E2F2 and E2F3 (Templeton et al. 1991, Helin et al. 1993, Otterson et al. 1997, Ji et al. 2004).
Identifier: R-HSA-9687136
Species: Homo sapiens
RB1 regulates mitotic exit by acting on SKP2, a component of the SCF E3 ubiquitin ligase complex. RB1 facilitates degradation of SKP2 by the anaphase promoting complex/cyclosome (APC/C), thus preventing SKP2-mediated degradation of the cyclin-dependent kinase inhibitor CDKN1B (p27Kip1). RB1-dependent accumulation of p27Kip1 plays an important role in mitotic exit and RB1-mediated tumor suppression (reviewed by Dyson 2016).
Identifier: R-HSA-9687139
Species: Homo sapiens
RB1 was the first tumor suppressor gene discovered. Bi-allelic loss of function of the RB1 gene, located at the chromosomal band 13q14, is the underlying cause of both familial and sporadic retinoblastoma, a pediatric eye cancer (reviewed by Lohmann and Gallie 2000, Knudson 2001, Corson and Gallie 2007). Besides retinoblastoma, carriers of germline RB1 mutations are predisposed to an array of other cancers, called second primary tumors, such as pinealoblastoma, osteosarcoma, leiomyosarcoma, rhabdomyosarcoma and melanoma (reviewed by Lohmann and Gallie 2000).

Inactivating somatic mutations in the RB1 gene are frequent in bladder cancer (Cancer Genome Atlas Research Network 2014), osteosarcoma (Ren and Gu 2017), ovarian cancer (Liu et al. 1994, Kuo et al. 2009, Cancer Genome Atlas Research Network 2011), small-cell lung carcinoma (reviewed by Gazdar et al. 2017), liver cancer (Ahn et al. 2014, Bayard et al. 2018) and esophageal cancer (Gao et al. 2014, Kishino et al. 2016, Salem et al. 2018).

The vast majority of RB1 mutations in cancer represent complete genomic deletions or nonsense and frameshift mutations that are predicted to result in null alleles. Missense mutations are rare and usually result in partially active RB1 mutants. Functionally characterized RB1 missense mutations and inframe deletions mostly affect pocket domains A and B and the nuclear localization signal (NLS). RB1 missense mutations reported in cancer are, however, scattered over the entire RB1 coding sequence and the molecular consequences of the vast majority of these mutations have not been studied (reviewed by Dick 2007).

The RB1 protein product, also known as pRB or retinoblastoma protein, is a nuclear protein that plays a major role in the regulation of the G1/S transition during mitotic cell cycle in multicellular eukaryotes. RB1 performs this function by binding to activating E2Fs (E2F1, E2F2 and E2F3), and preventing transcriptional activation of E2F1/2/3 target genes, which include a number of genes involved in DNA synthesis (reviewed by Classon and Harlow 2002, Dick 2007). RB1 also regulates mitotic exit by acting on SKP2, a component of the SCF E3 ubiquitin ligase complex. RB1 facilitates degradation of SKP2 by the anaphase promoting complex/cyclosome (APC/C), thus preventing SKP2-mediated degradation of the cyclin-dependent kinase inhibitor CDKN1B (p27Kip1). RB1-dependent accumulation of p27Kip1 plays an important role in mitotic exit and RB1-mediated tumor suppression (reviewed by Dyson 2016).

In addition to its role in regulation of the G1/S transition and mitotic exit, RB1 also performs other, non-canonical, functions, such as its role in the maintenance of genomic stability, which is linked to its role in chromosome condensation during mitotic prophase. The impact of RB1 mutations on these E2F-independent functions, which are still important for RB1-mediated tumor suppression, has been poorly studied (reviewed by Chau and Wang 2003, Burkhart and Sage 2008, Manning and Dyson 2012, Dyson 2016, Dick et al. 2018).
Identifier: R-HSA-9659787
Species: Homo sapiens
RB1 protein, also known as pRB or retinoblastoma protein, is a nuclear protein that plays a major role in the regulation of the G1/S transition during mitotic cell cycle in multicellular eukaryotes. RB1 performs this function by binding to activating E2Fs (E2F1, E2F2 and E2F3), and preventing transcriptional activation of E2F1/2/3 target genes, which include a number of genes involved in DNA synthesis. RB1 binds E2F1/2/3 through the so-called pocket region, which is formed by two parts, pocket domain A (amino acid residues 373-579) and pocket domain B (amino acid residues 640-771). Besides intact pocket domains, RB1 requires an intact nuclear localization signal (NLS) at its C-terminus (amino acid residues 860-876) to be fully functional (reviewed by Classon and Harlow 2002, Dick 2007). Functionally characterized RB1 mutations mostly affect pocket domains A and B and the NLS. RB1 mutations reported in cancer are, however, scattered over the entire RB1 coding sequence and the molecular consequences of the vast majority of these mutations have not been studied (reviewed by Dick 2007).

Many viral oncoproteins inactivate RB1 by competing with E2F1/2/3 for binding to the pocket region of RB1. RB1 protein is targeted by the large T antigen of the Simian virus 40 (SV40), the adenoviral E1A protein, and the E7 protein of oncogenic human papilloma viruses (HPVs) (reviewed by Classon and Harlow 2002).

Icon (1 results from a total of 1)

RB1

Species: Homo sapiens
Curator: Steve Jupe
Designer: Cristoffer Sevilla
RB1 icon
Retinoblastoma-associated protein
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