Search results for RBL1
Showing 20 results out of 20
Reaction (20 results from a total of 20)
Identifier: R-HSA-8964492
Species:
Homo sapiens
Compartment:
nucleoplasm
The DREAM complex binds the RBL1 (p107) gene promoter (Litovchick et al. 2007).
Identifier: R-HSA-8964525
Species:
Homo sapiens
Compartment:
nucleoplasm
The DREAM complex directly represses transcription of the RBL1 gene (Litovchick et al. 2007).
Identifier: R-HSA-8964588
Species:
Homo sapiens
Compartment:
nucleoplasm
In G0 and early G1, complexes containing p130 (RBL2) and p107 (RBL1), respectively, and histone deacetylase HDAC1 bind the promoter of the CCNA2 gene (Rayman et al. 2002).
Identifier: R-HSA-8978926
Species:
Homo sapiens
Compartment:
nucleoplasm
In G0 and early G1, complexes containing p130 (RBL2) and p107 (RBL1), respectively, and histone deacetylase HDAC1 directly inhibit transcription from the MYBL2 gene (Rayman et al. 2002).
Identifier: R-HSA-8964513
Species:
Homo sapiens
Compartment:
nucleoplasm
Transcription of the E2F1 gene is directly inhibited by the DREAM complex (Litovchick et al. 2007). E2F1 transcription is also directly inhibited by the complex of HDAC1 and RBL1 (p107) or RBL2 (p130) (Rayman et al. 2002).
Identifier: R-HSA-8961934
Species:
Homo sapiens
Compartment:
nucleoplasm
E2F1 directly stimulates transcription of the CDK1 gene, encoding cyclin-dependent kinase 1 (Cdc2) (Furukawa et al. 1994, DeGregori et al. 1995, Zhu et al. 2004). Transcription of the CDK1 gene is directly inhibited by complexes of HDAC1 and RBL1 (p107) or RBL2 (p130) in G1 and G0, respectively (Rayman et al. 2002).
Identifier: R-HSA-8964550
Species:
Homo sapiens
Compartment:
nucleoplasm
In G0 and early G1, complexes containing p130 (RBL2) and p107 (RBL1), respectively, and histone deacetylase HDAC1 bind the promoter of the E2F1 gene (Rayman et al. 2002).
Identifier: R-HSA-8964580
Species:
Homo sapiens
Compartment:
nucleoplasm
In G0 and early G1, complexes containing p130 (RBL2) and p107 (RBL1), respectively, and histone deacetylase HDAC1 bind the promoter of the CCNA2 gene (Rayman et al. 2002).
Identifier: R-HSA-8964567
Species:
Homo sapiens
Compartment:
nucleoplasm
In G0 and early G1, complexes containing p130 (RBL2) and p107 (RBL1), respectively, and histone deacetylase HDAC1 bind the promoter of the CDK1 gene (Rayman et al. 2002).
Identifier: R-HSA-8964561
Species:
Homo sapiens
Compartment:
nucleoplasm
In G0 and early G1, complexes containing p130 (RBL2) and p107 (RBL1), respectively, and histone deacetylase HDAC1 bind the promoter of the MYBL2 gene (Rayman et al. 2002).
Identifier: R-HSA-1227671
Species:
Homo sapiens
Compartment:
nucleoplasm
p107 (RBL1) in complex with E2F4 and DP1 or DP2 recruits histone deacetylase HDAC1 (possibly in complex with other chromatin modification proteins) through LXCXE-like motif, shared by pocket proteins, to repress transcription of E2F target genes in early G1.
Identifier: R-HSA-1363274
Species:
Homo sapiens
Compartment:
nucleoplasm
Dephosphorylation of p107 (RBL1) by PP2A complex containing either PPP2R3B (B" beta) or PPP2R2A (B alpha) regulatory subunit plays a role in maintaining the equilibrium of hyperphosphorylated and hypophosphorylated p107 (RBL1), through counteracting action of cyclin dependent kinases (CDKs) throughout the cell cycle. It is assumed that PP2A dephosphorylates p107 (RBL1) on all four phosphorylation sites, but further experiments are needed to confirm this.
Identifier: R-HSA-1363314
Species:
Homo sapiens
Compartment:
nucleoplasm
p107 (RBL1) is able to bind complexes of CDK2 with either cyclin A or cyclin E, through cyclin-binding LFG motif in the pocket domain, which is conserved in p130 (RBL2) and p21/WAF1/Cip1 family of cyclin-dependent kinase inhibitors. In addition to the LFG motif, the amino terminal sequence conserved in the p107 (RBL1) and p130 (RBL2) is needed for inhibition of CDK2 kinase activity. Presence of E2F is not required for this interaction.
Identifier: R-HSA-1226095
Species:
Homo sapiens
Compartment:
nucleoplasm
In late G1, cyclin D dependent kinases CDK4 and CDK6 phosphorylate RBL1 (p107) on four serine and threonine residues (S964, S975, T369 and S640), leading to dissociation of phosphorylated RBL1 (p107) from E2F4 in complex with either DP-1 or DP-2. E2F4, which lacks nuclear localization signal, is then thought to translocate to the cytosol, allowing E2F promoter sites to become occupied by activating E2Fs (E2F1, E2F2, and E2F3), resulting in transcription of E2F targets needed for cell cycle progression.
Identifier: R-HSA-1363311
Species:
Homo sapiens
Compartment:
nucleoplasm
p107 (RBL1) in complex with E2F4 and DP1/2 binds to cyclin A or cyclin E in complex with CDK2 through its conserved LFG pocket domain motif and amino terminus, leading to inhibition of CDK2 kinase activity and suppression of cellular growth.
Identifier: R-HSA-2127257
Species:
Homo sapiens
Compartment:
nucleoplasm
In response to TGF-beta stimulation, a complex composed of SMAD2/3:SMAD4 heterotrimer and RBL1 (p107), E2F4/5 and DP1/2 can be detected in the nucleus. Formation of this complex was confirmed by both co-immunoprecipitation of the endogenous complex from the human keratinocyte cell line HaCat and by protein interaction studies using tagged recombinant proteins. It is possible that cells contain pre-assembled cytosolic complexes of SMAD2/3, RBL1 (p107) and E2F4/5, that translocate to the nucleus after TGF-beta stimulation, when phosphorylated SMAD2/3 recruit SMAD4. The MH2 domain of SMAD3 establishes independent contacts with the N-termini of E2F4 (or E2F5) and unphosphorylated RBL1 (p107). RBL2 (p130), RB1 and E2F1 do not interact with SMAD2/3 (Chen et al. 2002).
Identifier: R-HSA-9736984
Species:
Homo sapiens
Compartment:
nucleoplasm
Complex formed by RBL1 (p107), E2F4/5, DP1/2 and a trimer of phosphorylated R-SMADs (SMAD2/3) and SMAD4 (Co-SMAD) cooperatively binds to TIE (TGF-beta inhibitory element) and E2F sites in the MYC gene promoter (Chen et al. 2002).
Identifier: R-HSA-1484099
Species:
Homo sapiens
Compartment:
nucleoplasm
Complex formed by RBL1 (p107), E2F4/5, DP1/2 and a trimer of phosphorylated R-SMADs (SMAD2/3) and SMAD4 (Co-SMAD) cooperatively binds to TIE (TGF-beta inhibitory element) and E2F sites in the MYC promoter and promotes cell-cycle independent inhibition of MYC transcription in response to TGF-beta stimulation (Chen et al. 2002).
Identifier: R-HSA-1363306
Species:
Homo sapiens
Compartment:
nucleoplasm
p130 (RBL2) is able to bind complexes of CDK2 with either cyclin A or cyclin E through the cyclin-binding LFG motif within the pocket domain, which is conserved in p107 (RBL1) and p21/WAF1/Cip1 family of cyclin-dependent kinases. In addition to LFG motif, amino terminal region of p130 (RBL2), conserved in p107 (RBL1), is necessary for inhibition of CDK2 kinase activity. Presence of E2F is not required for this interaction.
Identifier: R-HSA-6798282
Species:
Homo sapiens
Compartment:
nucleoplasm
The promoter of the CDC25C gene contains p53 response elements as well as E2F binding sites and can bind both TP53 (St Clair et al. 2004) and E2F4 (Benson et al. 2014). E2F4 transcription repressor complex consists of E2F4, a transcriptional co-factor TFDP1 (DP1) or TFDP2 (DP2), and a retinoblastoma family protein RBL1 (p107) or RBL2 (p130). The CDK inhibitor p21 (CDKN1A), induced by TP53, positively affects E2F4 recruitment to the CDC25C promoter, probably by upregulating RBL2 (Helmbold et al. 2009, Benson et al. 2014).
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