Search results for RCHY1

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Species

Types

Compartments

Reaction types

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Protein (2 results from a total of 2)

Identifier: R-HSA-5655134
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: RCHY1: Q96PM5
Identifier: R-HSA-976013
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: RCHY1: Q96PM5

Reaction (2 results from a total of 2)

Identifier: R-HSA-5655142
Species: Homo sapiens
Compartment: nucleoplasm
RCHY1 (Pirh2) is an E3 ubiquitin ligase that binds DNA polymerase eta (POLH). This interaction involves the polymerase-associated domain of POLH and the RING finger of RCHY1 (Jung et al. 2010).
Identifier: R-HSA-5655170
Species: Homo sapiens
Compartment: nucleoplasm
RCHY1 (Pirh2) acts as an E3 ubiquitin ligase to monoubiquitinate POLH (DNA polymerase eta) on lysine residues K682, K686, K694 and K709 located in the NLS (nuclear localization signal) of POLH (Jung et al. 2011). The NLS sequence of POLH is located between UBZ domain and PIP box, involved in POLH binding to monoubiquitinated PCNA (MonoUb:K164-PCNA). POLH monoubiquitination masks the PCNA-interaction region, thus disabling POLH binding to MonoUb:K164-PCNA and preventing POLH-mediated translesion DNA synthesis (TLS) (Bienko et al. 2010).
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