Search results for RDH5

Showing 13 results out of 13

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Protein (6 results from a total of 6)

Identifier: R-HSA-2471937
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: Q92781
Identifier: R-HSA-2471923
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: Q92781
Identifier: R-HSA-2471938
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: Q92781
Identifier: R-HSA-2471966
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: Q92781
Identifier: R-HSA-2471929
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: Q92781
Identifier: R-HSA-74825
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: RDH5: Q92781

Set (3 results from a total of 3)

Identifier: R-HSA-2471922
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Identifier: R-HSA-4084692
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
Identifier: R-HSA-5621635
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane

Reaction (3 results from a total of 3)

Identifier: R-HSA-2454081
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane, cytosol
Another member of the short-chain dehydrogenases/reductases (SDR) family, RDH5, can (reversibly) catalyse the oxidation of 11-cis-retinol (11cROL) to 11-cis-retinal (11cRAL) in retinal pigment epithelium (RPE) cells using NAD+ as cofactor (Simon et al. 1996, Gonzalez-Fernandez et al. 1999). Cellular retinaldehyde-binding protein (RLBP1), the protein bound to 11cRAL in RPE, is not present in photoreceptor cells.
Identifier: R-HSA-2466832
Species: Homo sapiens
Compartment: cytosol, endoplasmic reticulum membrane
11-cis-retinol dehydrogenase (RDH5) can reversibly catalyse the oxidation of all-trans-retinol (atROL, bound to RLBP1) to all-trans-retinal (atRAL) in retinal pigment epithelium (RPE) cells using NAD+ as cofactor. Defective RDH5 causes retinitis punctata albescens (RPA, also called fundus albipunctatus, FA; MIM:136880). RPA (an autosomal recessive disorder) is a form of stationary congenital night blindness characterised by a reduced regeneration rate of rod and cone photoreceptors and yellow-white lesions within the retina or the RPE. Mutations causing RPA include G238W (Gonzalez-Fernandez et al. 1999, Yamamoto et al. 1999), R280H (Gonzalez-Fernandez et al. 1999, Kuroiwa et al. 2000, Nakamura et al. 2000), A294P (Gonzalez-Fernandez et al. 1999), V177G (Gonzalez-Fernandez et al. 1999, Kuroiwa et al. 2000) and R157W (Cideciyan et al. 2000).
Identifier: R-HSA-5362721
Species: Homo sapiens
Compartment: cytosol, endoplasmic reticulum membrane
11-cis-retinol dehydrogenase (RDH5) and RDH11 catalyse the final step in the biosynthesis of 11-cis-retinal (11cRAL), the universal chromophore of visual pigments, whereas RDH8, RDH12, and DHRS3 (retSDR1) catalyze the conversion of all-trans-retinal (atRAL) into all-trans-retinol (atROL) to maintain the cycle (Parker & Crouch 2010). Defects in the RDH5 gene can cause fundus albipunctatus (RPA; MIM:136880), a rare form of stationary night blindness characterised by a delay in the regeneration of cone and rod photopigments (Yamamoto et al. 1999).

Icon (1 results from a total of 1)

Species: Homo sapiens
Curator: Bijay Jassal
Designer: Cristoffer Sevilla
RDH5 icon
Retinol dehydrogenase 5
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