Search results for RORC

Showing 7 results out of 7

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Species

Types

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Protein (2 results from a total of 2)

Identifier: R-HSA-446177
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: RORC: P51449
Identifier: R-HSA-8949306
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: RORC: P51449-2

DNA Sequence (1 results from a total of 1)

Identifier: R-HSA-8948433
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSG00000143365

Reaction (3 results from a total of 3)

Identifier: R-HSA-8949301
Species: Homo sapiens
Compartment: nucleoplasm
Based on mouse studies, binding of the RUNX3:CBFB heterodimer to the RUNX binding motif TGTGGT conserved between the mouse and human promoters of the RORC (RORgamma) gene, stimulates transcription of the RORC transcript variant 2 (RORC-2), also known as RORgT (RORgamma-t). In the ILC3 lineage of innate lymphoid cells in mice, expression of the Ahr transcription factor is positively indirectly regulated by Runx3, most likely through RORgT (Ebihara et al. 2015).
Identifier: R-HSA-8949276
Species: Homo sapiens
Compartment: nucleoplasm
Based on studies in mice, the complex of RUNX3 and CBFB binds the promoter of the RORC (RORgamma) gene, encoding nuclear retinoid-related orphan receptor-gamma. The RUNX binding site TGTGGT is conserved between mouse and human RORC promoters. Mouse Runx3 is expressed in innate lymphoid cell lineages ILC1 and ILC3, but not ILC2 (Ebihara et al. 2015).
Identifier: R-HSA-6790036
Species: Homo sapiens
Compartment: nucleoplasm
Signal transducer and activator of transcription 3 (STAT3) is a key regulator of gene expression in response to signaling of many cytokines including interleukin-6 (IL6), Oncostatin M, and leukemia inhibitory factor. Using microarray techniques, hundreds of genes have been reported as potential STAT3 target genes (Dauer et al. 2005, Hsieh et al. 2005). Some of these genes have been proven to be direct STAT3 targets using genome-wide chromatin immunoprecipitation screening (Snyder et al. 2008, Carpenter & Lo 2014). Genes for nuclear proteins upregulated by STAT3 include CCAAT/enhancer-binding protein delta (CEBPD) (Hutt et al. 2000), B-cell lymphoma 6 protein (BCL6) (Reljic et al. 2000), Myc proto-oncogene protein (MYC) (Kiuchi et al. 1999, Bowman et al. 2001), Proto-oncogene c-Fos (FOS) (Yang et al. 2003), Hypoxia-inducible factor 1-alpha (HIF1A) (Niu et al. 2008), Transcription factor SOX-2 (SOX2) (Foshay & Gallicano 2008), the homeobox protein NANOG (Okumura et al. 2011), Twist-related protein 1 (TWIST1) (Lo et al. 2007, Cheng et al. 2008), Zinc finger E-box-binding homeobox 1 (ZEB1) (Xiong et al. 2012), POU domain, class 2, transcription factor 1 (POU2F1) (OCT1) (Wang et al. 2013), Baculoviral IAP repeat-containing protein 5 (BIRC5, Survivin) (Gritsko et al. 2006), G1/S-specific cyclin-D1 (CCND1) (Leslie et al. 2006), Serine/threonine-protein kinase PIM1 (Przanowski et al. 2014), Forkhead box protein O1 (FOXO1), FOXO3 (Oh et al. 2011), Nuclear receptor ROR-alpha (RORA), RORC, Basic leucine zipper transcriptional factor ATF-like (BATF) (Durant et al. 2010) and Transcription factor JUNB (Coffer et al. 1995).

Pathway (1 results from a total of 1)

Identifier: R-HSA-8949275
Species: Homo sapiens
RUNX3-mediated transcription regulates development of immune system cells. RUNX3 is necessary for the development of innate lymphoid cells (ILCs) of ILC1 and ILC3 lineages, which reside in the mucosa and are involved in response to external pathogens. RUNX3 exerts its role in the development of ILC1 and ILC3 lineages by stimulating expression of the RORC (RORgamma) gene, encoding nuclear retinoid-related orphan receptor-gamma (Ebihara et al. 2015).
RUNX3 regulates transcription of integrin genes ITGAL (CD11a) and ITGA4 (CD49d), involved in transendothelial migration of leukocytes during immune and inflammatory responses as well as co-stimulation of T cells (Domniguez-Soto et al. 2005). The RUNX3 splicing isoform p33 lacks the Runt domain and is unable to transactivate integrin genes. The p33 isoform is induced during maturation of monocyte-derived dendritic cells (MDDC), leading to reduced expression of genes involved in inflammatory responses, such as IL8 (interleukin-8) (Puig-Kroger et al. 2010).
RUNX3 positively regulates transcription of the SPP1 (osteopontin) gene, which contributes to invasiveness of pancreatic cancer cells (Whittle et al. 2015).
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