Search results for SAMM50
Showing 2 results out of 2
Reaction (2 results from a total of 2)
Identifier: R-HSA-1268025
Species:
Homo sapiens
Compartment:
mitochondrial intermembrane space,
mitochondrial outer membrane
As inferred from the yeast SAM50 complex, the human SAMM50 Complex (SAM50 complex, TOB55 complex) inserts mainly beta-barrel proteins into the outer membrane after they have passed from the cytosol, through the TOMM40:TOMM70 complex, and into the intermembrane space.
In yeast, experimentally verified substrates of the SAM50 complex include TOM40 (TOMM40 in human), MDM10, Porin1 (VDAC1 in human), and TOM22 (TOMM22 in human). In humans, TOMM40 (Humphries et al. 2005) and VDAC1 (Kozjak-Pavlovic et al. 2007, homologous to yeast Porin1) have been shown to be substrates. Many other mitochondrial proteins are anticipated to be substrates of the SAMM50 complex.
In yeast, experimentally verified substrates of the SAM50 complex include TOM40 (TOMM40 in human), MDM10, Porin1 (VDAC1 in human), and TOM22 (TOMM22 in human). In humans, TOMM40 (Humphries et al. 2005) and VDAC1 (Kozjak-Pavlovic et al. 2007, homologous to yeast Porin1) have been shown to be substrates. Many other mitochondrial proteins are anticipated to be substrates of the SAMM50 complex.
Identifier: R-HSA-9714477
Species:
Homo sapiens
Compartment:
mitochondrial outer membrane
RAC2 interacts with several effectors localized at the mitochondrial outer membrane. Since RAC2 localization at the mitochondrial outer membrane and its association with mitochondrial proteins has not been fully established, these effectors are annotated as candidates:
ARMCX3 (Bagci et al. 2020)
MTX1 (Capala et al. 2015)
SAMM50 (Capala et al. 2015)
ARMCX3 (Bagci et al. 2020)
MTX1 (Capala et al. 2015)
SAMM50 (Capala et al. 2015)
© 2024 Reactome
