Search results for SAT1

Showing 6 results out of 6

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Species

Types

Compartments

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Protein (3 results from a total of 3)

Identifier: R-HSA-351236
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: SAT1: P21673
Identifier: R-HSA-427580
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: SLC26A1: Q9H2B4
Identifier: R-HSA-212663
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: SLC38A1: Q9H2H9

Reaction (3 results from a total of 3)

Identifier: R-HSA-427555
Species: Homo sapiens
Compartment: plasma membrane
The SLC26A1 and 2 genes encode proteins that facilitate sulfate (SO4(2-)) uptake into cells (Alper & Sharma 2013). The mechanism by which these transporters work is unclear but may be enhanced by extracellular halides or acidic pH environments, cotransporting protons electroneutrally. Both can transport SO4(2-) (as well as oxalate and Cl-) across the basolateral membrane of epithelial cells. SLC26A1 encodes the sulfate anion transporter 1 (SAT1) (Regeer et al. 2003) and is most abundantly expressed in the liver and kidney, with lower levels expressed in many other parts of the body. SLC26A2 is ubiquitously expressed and encodes a sulfate transporter (Diastrophic dysplasia protein, DTD, DTDST) (Hastbacka et al. 1994). This transporter provides sulfate for sulfation of glycosaminoglycan chains in proteoglycans needed for cartilage development. Defects in SLC26A2 are implicated in the pathogenesis of several human chondrodysplasias.
Identifier: R-HSA-351208
Species: Homo sapiens
Compartment: cytosol
Spermidine/spermine N1-acetyltransferase (Spd/Spm acetyltransferase) is the rate-limiting enzyme in the catabolism of polyamines. Defects in SAT1 may be the cause of keratosis follicularis spinulosa decalvans (KFSD).
Identifier: R-HSA-351207
Species: Homo sapiens
Compartment: cytosol
Spermidine/spermine N1-acetyltransferase (Spd/Spm acetyltransferase) is the rate-limiting enzyme in the catabolism of polyamines. Defects in SAT1 may be the cause of keratosis follicularis spinulosa decalvans (KFSD).
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