Search results for SDC2

Showing 13 results out of 31

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Protein (10 results from a total of 28)

Identifier: R-HSA-8956741
Species: Homo sapiens
Compartment: endoplasmic reticulum lumen
Primary external reference: UniProt: SDC2: P34741
Identifier: R-HSA-2054101
Species: Homo sapiens
Compartment: Golgi lumen
Primary external reference: UniProt: P34741
Identifier: R-HSA-2090083
Species: Homo sapiens
Compartment: lysosomal lumen
Primary external reference: UniProt: P34741
Identifier: R-HSA-2090052
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P34741
Identifier: R-HSA-2076683
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: SDC2: P34741
Identifier: R-HSA-2064109
Species: Homo sapiens
Compartment: Golgi lumen
Primary external reference: UniProt: SDC2: P34741
Identifier: R-HSA-4093306
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: SDC2: P34741
Identifier: R-HSA-8956945
Species: Homo sapiens
Compartment: endoplasmic reticulum lumen
Primary external reference: UniProt: P34741
Identifier: R-HSA-2076644
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P34741
Identifier: R-HSA-2090064
Species: Homo sapiens
Compartment: lysosomal lumen
Primary external reference: UniProt: P34741

Reaction (2 results from a total of 2)

Identifier: R-HSA-4093342
Species: Homo sapiens
Compartment: plasma membrane
Syndecan-2 (SDC2), upon phosphorylation by EPHB2, undergoes multimerization and clustering on dendrites leading to spinogenesis. Pathways downstream of SDC2 that ultimately leads to cytoskeletal rearrangement of the spine have yet to be elucidated. Ethell et al. hypothesised that EPHB2 may associate with SDC2 after clustering and localise SDC2 to sites of nascent spines. Subsequent recruitment of syntenin and CASK by SDC2 via PDZ interactions may promote spinogenesis (Ethell et al. 2001, Lin et al. 2007).
Identifier: R-HSA-4093332
Species: Homo sapiens
Compartment: plasma membrane, cytosol
Syndecans (SDCs) are a major class of cell surface heparan sulphate proteoglycans (HSPGs) and the member syndecan-2 (SDC2) plays a critical role in EPHB-mediated spine formation in hippocampal neurons. Ethell et al. suggest that one of the mechanisms by which EPHB receptors regulate spine morphology is through phosphorylation of SDC2 (Ethell et al. 2001, Ethell & Yamaguchi 1999). Activated EPHB2 phosphorylates SDC2 at tyrosine residues Y189 and Y201 (Y179 and Y191 according to uniprot reference sequence) in the C1 and V regions respectively (Ethell et al. 2001).

Polymer (1 results from a total of 1)

Identifier: R-HSA-4093309
Species: Homo sapiens
Compartment: plasma membrane
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