Search results for SEPT2

Showing 5 results out of 5

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Species

Types

Compartments

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Protein (1 results from a total of 1)

Identifier: R-HSA-5626657
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: SEPTIN2: Q15019

Interactor (3 results from a total of 3)

Identifier: Q15019-2
Species: Homo sapiens
Primary external reference: UniProt: Q15019-2
Identifier: Q15019-1
Species: Homo sapiens
Primary external reference: UniProt: Q15019-1
Identifier: Q15019-3
Species: Homo sapiens
Primary external reference: UniProt: Q15019-3

Reaction (1 results from a total of 1)

Identifier: R-HSA-5626681
Species: Homo sapiens
Compartment: cytosol
The transition zone is a protein-rich zone at the base of the cilium that forms after maturation of the mother centriole and prior to or concurrent with the initiation of intraflagellar transport (IFT) (reviewed in Benzing and Schermer, 2011; Reiter et al, 2012). The transition zone consists of a growing number of proteins and protein complexes, many of whose genes are associated with ciliopathies such as nephronophthisis, Meckel-Gruber syndrome and Joubert's syndrome (Reiter et al, 2006; Hu et al, 2010; Sang et al, 2011; Williams et al, 2011; Garcia-Gonzalo et al, 2011; Chih et al, 2012; reviewed in Reiter et al, 2012). In conjunction with SEPT2, which was recently shown to form a septin ring diffusion barrier at the base of the cilium, the transition zone and its resident proteins contribute to protein sorting and ciliary membrane composition and act as a ciliary gate (Hu et al, 2010; Williams et al, 2011; Garcia-Gonzalo et al, 2011; Chih et al, 2012; reviewed in Reiter et al, 2012).
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