Deleted in malignant brain tumors 1 protein (DMBT1 aka Gp-340, Hensin, salivary agglutinin) is a binding protein that could play a role in mucosal innate immunity. It is secreted into the broncho-alveolar surface lining fluid and in saliva. DMTB1 can bind surfactant proteins SFTPA and D in macrophage tissues, the resulting complex being able to interact with and agglutinate several Gram-negative and Gram-positive bacteria (Holmskov et al. 1999, Ligtenberg et al. 2001; reviews - Lightenberg et al. 2007, Madsen et al. 2010). DMBT1 has been proposed as a tumor suppressor gene candidate in human brain tumors. Two mutations, one of which resulted in an amino acid change (Q420H), occurred in glioblastomas (Mueller et al. 2002).