Search results for SFTPD

Showing 18 results out of 26

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Species

Types

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Protein (4 results from a total of 4)

Identifier: R-HSA-391099
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: SFTPD: P35247
Identifier: R-HSA-5685641
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: SFTPD: P35247
Identifier: R-HSA-5686343
Species: Homo sapiens
Compartment: clathrin-coated endocytic vesicle
Primary external reference: UniProt: P35247
Identifier: R-HSA-5685278
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: P35247

DNA Sequence (1 results from a total of 1)

Identifier: R-HSA-5685277
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: SFTPD: ENSG00000133661

Reaction (5 results from a total of 8)

Identifier: R-HSA-5685290
Species: Homo sapiens
Compartment: nucleoplasm, endoplasmic reticulum membrane
The human gene SFTPD produces pulmonary surfactant-associated protein D. The final processed product is a 12mer consisting of four sets of SFTPD trimer (Rust et al. 1991, Lu et al. 1992, Hakansson et al. 1999). It is secreted into the pulmonary alveoli. In addition to its surfactant-related functions, SFTPD, like SFTPA, contributes to the lung's defense against inhaled pathogens and allergens by binding and clearing these entities from the lung (Lu et al. 1992, Crouch et al. 1993) (not annotated here).
Identifier: R-HSA-8961021
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
The human gene SFTPD produces pulmonary surfactant-associated protein D. The final processed product is a 12mer consisting of four sets of SFTPD trimer (Rust et al. 1991, Lu et al. 1992, Hakansson et al. 1999). It is secreted into the pulmonary alveoli. In addition to its surfactant-related functions, SFTPD, like SFTPA, contributes to the lung's defense against inhaled pathogens and allergens by binding and clearing these entities from the lung.
Identifier: R-HSA-5687284
Species: Homo sapiens
Compartment: extracellular region
Deleted in malignant brain tumors 1 protein (DMBT1 aka Gp-340, Hensin, salivary agglutinin) is a binding protein that could play a role in mucosal innate immunity. It is secreted into the broncho-alveolar surface lining fluid and in saliva. DMTB1 can bind surfactant proteins SFTPA and D in macrophage tissues, the resulting complex being able to interact with and agglutinate several Gram-negative and Gram-positive bacteria (Holmskov et al. 1999, Ligtenberg et al. 2001; reviews - Lightenberg et al. 2007, Madsen et al. 2010). DMBT1 has been proposed as a tumor suppressor gene candidate in human brain tumors. Two mutations, one of which resulted in an amino acid change (Q420H), occurred in glioblastomas (Mueller et al. 2002).
Identifier: R-HSA-391155
Species: Homo sapiens
Compartment: extracellular region, plasma membrane
Pulmonary surfactant-associated proteins A1, A2 and D (SFTPA1, SFTPA2 and SFTPD) are soluble multivalent ligands shown to bind SIRP alpha (SIRPA) on resident alveolar cells and macrophages via their lectin domain (globular head). SFTPA and SFTPD bind to the same region of SIRPA as CD47, blocking subsequent binding of CD47.
Identifier: R-HSA-9624778
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane, extracellular region
The pulmonary collectins, surfactant proteins A1, A2, A3 and D (SFTPAs, SFTPD 12mer), play important roles in innate host defense by binding and clearing invading microbes from the lung. They also influence surfactant homeostasis, contributing to the physical structures of lipids in the alveoli and to the regulation of surfactant function and metabolism. They are directly secreted from alveolar type II cells into the airway to function as part of the surfactant. The mechanism of secretion is unknown (Andreeva et al. 2007).

Polymer (1 results from a total of 1)

Identifier: R-HSA-391097
Species: Homo sapiens
Compartment: extracellular region

Complex (5 results from a total of 10)

Identifier: R-HSA-391098
Species: Homo sapiens
Compartment: extracellular region
Identifier: R-HSA-5686241
Species: Homo sapiens
Compartment: extracellular region
Identifier: R-HSA-5686263
Species: Homo sapiens
Compartment: extracellular region
Identifier: R-HSA-5686361
Species: Homo sapiens
Compartment: clathrin-coated endocytic vesicle
Identifier: R-HSA-5686333
Species: Homo sapiens
Compartment: clathrin-coated endocytic vesicle

Set (2 results from a total of 2)

Identifier: R-HSA-391108
Species: Homo sapiens
Compartment: extracellular region
Identifier: R-HSA-5687334
Species: Homo sapiens
Compartment: extracellular region
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