CBL recruits the complex of SH3KBP1 (CIN85) and endophilin to the activated MET receptor. While CIN85 and endophilin are not involved in CBL tyrosine phosphorylation by activated MET and CBL-mediated MET ubiquitination, they are required for internalization and degradation of the activated MET receptor (Petrelli et al. 2002). CIN85 likely functions as a homotetramer (Watanabe et al. 2000). Endophilin A1 (SH3GL2), A2 (SH3GL1) and A3 (SH3GL3), which function as homodimers, can all be recruited to the activated MET receptor, with SH3GL3 being the most extensively studied (Petrelli et al. 2002).