Search results for SLC25A1

Showing 16 results out of 24

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Protein (6 results from a total of 14)

Identifier: R-HSA-372445
Species: Homo sapiens
Compartment: mitochondrial inner membrane
Primary external reference: UniProt: SLC25A1: P53007
Identifier: R-HSA-198451
Species: Homo sapiens
Compartment: mitochondrial inner membrane
Primary external reference: UniProt: SLC25A11: Q02978
Identifier: R-HSA-372848
Species: Homo sapiens
Compartment: mitochondrial inner membrane
Primary external reference: UniProt: SLC25A10: Q9UBX3
Identifier: R-HSA-5215935
Species: Homo sapiens
Compartment: mitochondrial inner membrane
Primary external reference: UniProt: SLC25A19: Q9HC21
Identifier: R-HSA-199229
Species: Homo sapiens
Compartment: mitochondrial inner membrane
Primary external reference: UniProt: SLC25A16: P16260
Identifier: R-HSA-372485
Species: Homo sapiens
Compartment: mitochondrial inner membrane
Primary external reference: UniProt: SLC25A13: Q9UJS0

Set (2 results from a total of 2)

Identifier: R-HSA-372469
Species: Homo sapiens
Compartment: mitochondrial inner membrane
Identifier: R-HSA-8875842
Species: Homo sapiens
Compartment: mitochondrial inner membrane

Complex (1 results from a total of 1)

Identifier: R-HSA-376856
Species: Homo sapiens
Compartment: mitochondrial inner membrane

Reaction (6 results from a total of 6)

Identifier: R-HSA-75849
Species: Homo sapiens
Compartment: cytosol
SLC25A1, in the inner mitochondrial membrane, mediates the exchange of mitochondrial citrate for cytosolic malate (Edvarson et al.2013, Gnoni et al.2009).
Identifier: R-HSA-372448
Species: Homo sapiens
Compartment: cytosol, mitochondrial inner membrane, mitochondrial matrix
Calcium-binding mitochondrial carrier proteins Aralar1 and Aralar2 (SLC25A12 and SLC25A13 respectively), located in the inner mitochondrial membrane, mediate the exchange of cytosolic aspartate and mitochondrial glutamate (Palmieri et al. 2001). The exchange is physiologically irreversible because of the potential across the inner mitochondrial membrane (positive outside, negative inside). In the body, SLC25A12 is found mainly in heart, skeletal muscle, and brain, while SCL25A13 is widely expressed but most abundant in liver (del Arco et al. 2000; Palmieri et al. 2001). Defects in SLC25A13 are associated with type II citrullinemia, characterised by a liver-specific deficiency of the urea cycle enzyme argininosuccinate synthase (Kobayashi et al. 1999, Saheki et al. 2002).
Identifier: R-HSA-8875838
Species: Homo sapiens
Compartment: mitochondrial intermembrane space, mitochondrial inner membrane, mitochondrial matrix
Mitochondrial thiamine pyrophosphate carrier (SLC25A19, DNC, MUP1) was originally thought to be a deoxyribonucleotide (DNC) carrier but has since been identified from enzyme kinetics, gene knockout studies and clinical samples from Amish Microcephaly (MCPHA) patients, to be a transporter of thiamine pyrophosphate (ThDP) into mitochondria (Kang & Samuels 2008). ThDP is a cofactor for the mitochondrial enzymes pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, and branched chain amino acid dehydrogenase. The biochemical phenotype of MCPHA may be attributable to decreased activity of these enzymes (Siu et al. 2010).
Identifier: R-HSA-199216
Species: Homo sapiens
Compartment: mitochondrial inner membrane
Graves disease carrier protein (SLC25A16), associated with the inner mitochondrial membrane, mediates the transport of cytosolic coenzyme A (CoA-SH) into the mitochondrial matrix. Evidence for this event is indirect. The protein has the sequence motifs expected for a transport protein, and yeast cells deficient in its homologue, Leu5p, fail to accumulate mitochondrial CoA-SH and can be rescued by expression of SLC25A16. At the same time, neither the yeast nor the human protein has been shown directly to function as a transporter (Prohl et al. 2001, Leonardi et al. 2007).
Identifier: R-HSA-8875623
Species: Homo sapiens
Compartment: cytosol, mitochondrial inner membrane, mitochondrial matrix
Mitochondrial glutamate carriers 1 and 2 (SLC25A22, GC1 and SLC25A18, GC2) belong to the mitochondrial carrier family of transport proteins which shuttle substrates, metabolites and cofactors through the mitochondrial membrane, connecting the cytosol to the mitochondrial matrix. Glutamate (Glu) can be co-transported with H+ via SLC25A18 and SLC25A22, located on the inner mitochondrial membrane (Fiermonte et al. 2002). Defects in SLC25A22 can cause early infantile epileptic encephalopathy 3 (EIEE3; MIM:609304), a severe neonatal epilepsy characterised by a very early onset, erratic and fragmentary myoclonus. With no treatment available, children with EIEE3 die within 1 or 2 years of birth or survive in a vegetative state (Molinari et al. 2005).
Identifier: R-HSA-372449
Species: Homo sapiens
Compartment: cytosol, mitochondrial inner membrane, mitochondrial matrix
SLC25A1, in the inner mitochondrial membrane, mediates the exchange of cytosolic citrate for mitochondrial phosphoenolpyruvate. The exchange is physiologically irreversible because of the potential of the inner mitochondrial membrane. The gene encoding human SLC25A1 has been cloned and its expression pattern has been characterized (Heisterkamp et al. 1995; Iacobazzi et al. 1997), but the biochemical details of the transport process are inferred from those worked out for the well-characterized rat system (Robinson 1971; Soling et al. 1971; Kleineke et al. 1973).

Icon (1 results from a total of 1)

Species: Homo sapiens
Curator: Bijay Jassal
Designer: Cristoffer Sevilla
SLC25A1 icon
Tricarboxylate transport protein, mitochondrial
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