Search results for SLC25A17

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Protein (2 results from a total of 2)

Identifier: R-HSA-389642
Species: Homo sapiens
Compartment: peroxisomal membrane
Primary external reference: UniProt: SLC25A17: O43808
Identifier: R-HSA-9603781
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: SLC25A17: O43808

Reaction (1 results from a total of 1)

Identifier: R-HSA-9603804
Species: Homo sapiens
Compartment: cytosol
In the cytosol, PEX19 binds newly synthesized class I peroxisomal membrane proteins (Sacksteder et al. 2000, Fransen et al. 2001, Jones et al. 2004, reviewed in Fujiki et al. 2006). The C-terminal region and a conserved N-terminal helical segment of PEX19 bind to peroxisomal membrane proteins (Fransen et al. 2005, Schueller et al. 2010) and PEX19 acts both as a chaperone and as an import receptor (Jones et al. 2004). PEX19 is farnesylated (Götte et al. 1998, Sacksteder et al. 2000, Vastiau et al. 2006) and the farnesyl group is buried in a hydrophobic cavity which alters the conformation of PEX19 to yield two hydrophobic pockets involved in binding peroxisomal membrane proteins (Emmanouilidis et al. 2017). The number of positively charged amino acid residues in the transmembrane domain of the PMP appears to determine binding by PEX19 and, hence, targeting to the peroxisomal membrane protein (Costello et al. 2017).
Class I membrane proteins are inserted into the peroxisomal membrane after peroxisomal progenitors have budded from the endoplasmic reticulum (Jones et al. 2004). Human class I peroxisomal membrane proteins that are bound by PEX19 include PEX10 (Sacksteder et al. 2000), PEX11B (Fransen et al. 2005), PEX12 (Sacksteder et al. 2000, Fransen et al. 2001, Fransen et al. 2005), PEX13 (Sacksteder et al. 2000, Fransen et al. 2001, Fransen et al. 2005, Vastiau et al. 2006, Liu et al. 2016), PEX14 (Sacksteder et al. 2000, Fransen et al. 2005, Vastiau et al. 2006), PEX16 (Fransen et al. 2001, Fransen et al. 2005, Matsuzono and Fujiki 2006, Schueller et al. 2010, Yagita et al. 2013, Liu et al. 2016), ), PEX26 (Fransen et al. 2005, Matsuzono and Fujiki 2006), ABCD1 (ALDP, Mayerhofer et al. 2002, Halbach et al. 2005), ABCD2 (ALDRP, Mayerhofer et al. 2002), ABCD3 (PMP70, Sacksteder et al. 2000, Mayerhofer et al. 2002), PXMP2 (PMP22, Jones et al. 2001, Brosius et al. 2002), PXMP4 (PMP24, Pinto et al. 2006), SLC25A17 (PMP34, Sacksteder et al. 2000, Liu et al. 2016), ATAD1 (Liu et al. 2016), FIS1 (Delille and Schrader 2008), and GDAP1 (Huber et al. 2013).
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