Search results for SLC5A5

Showing 11 results out of 11

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Species

Types

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Protein (7 results from a total of 7)

Identifier: R-HSA-209833
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: SLC5A5: Q92911
Identifier: R-HSA-5658166
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: SLC5A5: Q92911
Identifier: R-HSA-5658167
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: Q92911
Identifier: R-HSA-5658196
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: Q92911
Identifier: R-HSA-5658172
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: Q92911
Identifier: R-HSA-5658157
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: Q92911
Identifier: R-HSA-5658154
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: Q92911

Set (1 results from a total of 1)

Identifier: R-HSA-5658206
Species: Homo sapiens
Compartment: plasma membrane

Reaction (2 results from a total of 2)

Identifier: R-HSA-429591
Species: Homo sapiens
Compartment: plasma membrane, cytosol, extracellular region
Human SLC5A5 encodes a Na+/I- symporter, NIS (Smanik et al. 1996). NIS is localized in the basolateral membrane facing the bloodstream and mediates iodide accumulation into thyrocytes. Defects in SLC5A5 cause congenital hypothyroidism due to dyshormonogenesis type 1 (CHDH1) (Fujiwara et al. 1997). NIS, together with AIT (see next reaction), mediates iodide transfer from blood to the colloid lumen of thyrocytes.
Identifier: R-HSA-5658195
Species: Homo sapiens
Compartment: plasma membrane, extracellular region
Human SLC5A5 encodes the Na+/I- symporter NIS which is localised in the basolateral membrane of thyrocytes facing the bloodstream where it mediates iodide accumulation into these cells. Defects in SLC5A5 can cause hyroid dyshormonogenesis 1 (TDH1; MIM:274400), a disorder characterised by the inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland (termed iodine trapping) leading to congenital hypothyroidism. Mutations in SLC5A5 that can cause TDH1 include T354P, V59E, G395R, C272*, G93R and R124H (Fujiwara et al. 1997, Pohlenz et al. 1997, Kosugi et al. 1998, 1999).

Pathway (1 results from a total of 1)

Identifier: R-HSA-5619096
Species: Homo sapiens
Human SLC5A5 encodes the Na+/I- symporter NIS which is localised in the basolateral membrane of thyrocytes facing the bloodstream where it mediates iodide accumulation into these cells. Defects in SLC5A5 can cause hyroid dyshormonogenesis 1 (TDH1; MIM:274400), a disorder characterised by the inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland (termed iodine trapping) leading to congenital hypothyroidism (Spitzweg & Morris 2010, Grasberger & Refetoff 2011).
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