Search results for SLC6A8

Showing 4 results out of 4

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Species

Types

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Species

Types

Compartments

Search properties

Protein (1 results from a total of 1)

Identifier: R-HSA-200393
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: SLC6A8: P48029

Set (1 results from a total of 1)

Identifier: R-HSA-3902491
Species: Homo sapiens
Compartment: plasma membrane
This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.

Reaction (1 results from a total of 1)

Identifier: R-HSA-200396
Species: Homo sapiens
Compartment: plasma membrane
The SLC6A8 transport protein associated with the plasma membrane mediates the uptake of extracellular creatine and a sodium ion (Sora et al. 1994). Molecular and biochemical studies of patients deficient in SLC6A8 protein confirm this function in vivo (e.g., Salomons et al. 2003).

Pathway (1 results from a total of 1)

Identifier: R-HSA-71288
Species: Homo sapiens
Compartment: mitochondrial inner membrane, mitochondrial intermembrane space, cytosol, plasma membrane
In humans, creatine is synthesized primarily in the liver and kidney, from glycine, arginine, and S-adenosylmethionine, in a sequence of two reactions. From the liver, creatine is exported to tissues such as skeletal muscle and brain, where it undergoes phosphorylation and serves as a short-term energy store. The mechanism by which creatine leaves producer tissues is unclear, but its uptake by consumer tissues is mediated by the SLC6A8 transporter.

Once formed, phosphocreatine undergoes a slow spontaneous reaction to form creatinine, which is excreted from the body.

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