Search results for SMPD2

Showing 8 results out of 8

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Species

Types

Compartments

Reaction types

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Protein (1 results from a total of 1)

Identifier: R-HSA-194337
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: SMPD2: O60906

Reaction (3 results from a total of 3)

Identifier: R-HSA-1606273
Species: Homo sapiens
Compartment: plasma membrane, cytosol
The mammalian brain-specific, Mg2+-dependent, neutral sphingomyelin phosphodiesterases 2 (Tomiuk et al. 1998, Hofmann et al. 2000) and 3 (Marchesini et al. 2003) (SMPD2 and 3) hydrolyse sphingomyelin (SPHM) to ceramide (CERA) at the plasma membrane.
Identifier: R-HSA-5626981
Species: Homo sapiens
Compartment: plasma membrane
Sphingolipid signaling is initiated by neutral sphingomyelinase (neutral SMASE), a family of agonist-activated effector enzymes.
Identifier: R-HSA-5626988
Species: Homo sapiens
Compartment: cytosol, plasma membrane
TNF-α-induced signaling by TNFR1 promotes the activation of sphingomyelin phosphodiesterase (sphingomyelinase or SMASE) signaling pathways. SMASE is a family of an agonist-activated effector enzymes that hydrolyze phospholipids on the membrane compartments to produce ceramide, a lipid-signaling molecule.

Factor associated with neutral sphingomyelinase activation (FAN or NSMAF) is an adaptor protein that constitutively binds to the neutral SMASE activation domain (NSD) of TNFR1 (Adam-Klages S et al. 1996). NSMAF (FAN) is thought to directly link TNFR1 to the activation of neutral sphingomyelinase (N-SMASE) such as sphingomyelin phosphodiesterase 2 or 3 (SMPD2, SMPD3).

Set (1 results from a total of 1)

Identifier: R-HSA-1606272
Species: Homo sapiens
Compartment: plasma membrane

Complex (2 results from a total of 2)

Identifier: R-HSA-1606266
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-5626990
Species: Homo sapiens
Compartment: plasma membrane

Icon (1 results from a total of 1)

Species: Homo sapiens
Sphingomyelin phosphodiesterase 2
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