Search results for SMPD3

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Species

Types

Compartments

Reaction types

Search properties

Protein (1 results from a total of 1)

Identifier: R-HSA-1606265
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: SMPD3: Q9NY59

Reaction (1 results from a total of 1)

Identifier: R-HSA-5626988
Species: Homo sapiens
Compartment: cytosol, plasma membrane
TNF-alpha-induced signaling by TNFR1 promotes the activation of sphingomyelin phosphodiesterase (sphingomyelinase or SMASE) signaling pathways. SMASE is a family of an agonist-activated effector enzymes that hydrolyze phospholipids on the membrane compartments to produce ceramide, a lipid-signaling molecule.

Factor associated with neutral sphingomyelinase activation (FAN or NSMAF) is an adaptor protein that constitutively binds to the neutral SMASE activation domain (NSD) of TNFR1 (Adam-Klages S et al. 1996). NSMAF (FAN) is thought to directly link TNFR1 to the activation of neutral sphingomyelinase (N-SMASE) such as sphingomyelin phosphodiesterase 2 or 3 (SMPD2, SMPD3).

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