Search results for SMYD2

Showing 6 results out of 6

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Protein (1 results from a total of 1)

Identifier: R-HSA-3222233
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: SMYD2: Q9NRG4

Reaction (3 results from a total of 3)

Identifier: R-HSA-3222237
Species: Homo sapiens
Compartment: nucleoplasm
The lysine methyltransferase SMYD2 methylates TP53 (p53) on lysine residue K370, thus repressing TP53 transcriptional activity. The methylation at K370 is inhibited if TP53 is pre-methylated at K372 (Huang et al. 2006).
Identifier: R-HSA-4827383
Species: Homo sapiens
Compartment: nucleoplasm
Methylation of histone H3 lysine-37 (H3K36) is tightly associated with actively transcribed genes and appears to correspond primarily with coding regions (Wagner & Carpenter 2011).

WHSC1 (KMT3G, NSD2, MMSET), a member of the SET2 family, dimethylates H3K36 when provided with nucleosome substrates (Li et al 2009; Qiao et al. 2011). Dimethylation of histone H3 at lysine-37 (H3K36me2) is thought to be the principal chromatin-regulatory activity of WHSC1 (Kuo et al. 2011), SMYD2 (KMT3C) (Brown et al 2006) and NSD1 (KMT3B) (Li et al. 2009, Qiao et al. 2011).
Identifier: R-HSA-5638157
Species: Homo sapiens
Compartment: nucleoplasm
Methylation of histone H3 lysine-37 (H3K36) is tightly associated with actively transcribed genes and appears to correspond primarily with coding regions (Wagner & Carpenter 2011). WHSC1 (KMT3G, NSD2, MMSET), a member of the SET2 family, dimethylates H3K36 when provided with nucleosome substrates (Li et al 2009; Qiao et al. 2011). Dimethylation of histone H3 at lysine-37 (H3K36me2) is thought to be the principal chromatin-regulatory activity of WHSC1 (Kuo et al. 2011), SMYD2 (KMT3C) (Brown et al 2006) and NSD1 (KMT3B) (Li et al. 2009, Qiao et al. 2011). ASH1L can perform histone H3 lysine-37 di-methylation (Tanaka et al. 2007, An et al. 2011, Miyazaki et al. 2013, Zhu et al. 2016).

Set (1 results from a total of 1)

Identifier: R-HSA-4827375
Species: Homo sapiens
Compartment: nucleoplasm

Pathway (1 results from a total of 1)

Identifier: R-HSA-6804760
Species: Homo sapiens
TP53 (p53) undergoes methylation on several lysine and arginine residues, which modulates its transcriptional activity.

PRMT5, recruited to TP53 as part of the ATM-activated complex that includes TTC5, JMY and EP300 (p300), methylates TP53 arginine residues R333, R335 and R337. PRMT5-mediated methylation promotes TP53-stimulated expression of cell cycle arrest genes (Shikama et al. 1999, Demonacos et al. 2001, Demonacos et al. 2004, Adams et al. 2008, Adams et al. 2012). SETD9 (SET9) methylates TP53 at lysine residue K372, resulting in increased stability and activity of TP53 (Chuikov et al. 2004, Couture et al. 2006, Bai et al. 2011).

TP53 transcriptional activity is repressed by SMYD2-mediated methylation of TP53 at lysine residue K370 (Huang et al. 2006). Dimethylation of TP53 at lysine residue K373 by the complex of methyltransferases EHMT1 and EHMT2 also represses TP53-mediated transcription (Huang et al. 2010). The chromatin compaction factor L3MBTL1 binds TP53 monomethylated at lysine K382 by SETD8 (SET8) and, probably through changing local chromatin architecture, represses transcription of TP53 targets (West et al. 2010). The histone lysine-specific demethylase LSD1 interacts with TP53 and represses p53-mediated transcriptional activation (Huang et al. 2007). PRMT1 and CARM1 can also modulate p53 functions in a cooperative manner (An et al. 2004).

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