Search results for SOCS6

Showing 8 results out of 8

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Species

Types

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Reaction types

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Protein (1 results from a total of 1)

Identifier: R-HSA-1469969
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: SOCS6: O14544

Reaction (3 results from a total of 3)

Identifier: R-HSA-9706330
Species: Homo sapiens
Compartment: plasma membrane, cytosol
The E3 ubiquitin ligase SOCS6 binds to tyrosine phosphorylated FLT3 through Y591 and Y919. SOCS6 contributes to the ubiquitination and degradation of the active FLT3 receptor (Kazi et al, 2012; reviewed in Kazi et al, 2014).
Identifier: R-HSA-1470011
Species: Homo sapiens
Compartment: plasma membrane, extracellular region, cytosol
SOCS6 protein interacts with the phosphorylated Y568 in the juxtamembrane domain of c-Kit following SCF-stimulated tyrosine phosphorylation. Binding of SOCS6 to Y568 may mask this docking site for Src family kinases and this may inhibit the phosphorylation of p38 and ERK. This negatively regulates c-Kit receptor proliferation signal but not SCF-induced chemotaxis (Bayle et al. 2004, Zadjali et al 2011). Binding of SOCS6 mediates recruitment of elongin B and C to form a ubiquitin E3 ligase complex that leads to ubiquitination of KIT and its degradation (Zadjali et al 2011).
Identifier: R-HSA-9706354
Species: Homo sapiens
Compartment: plasma membrane
FLT3 activity is negatively regulated by ubiquitin-mediated internalization (Sargin et al, 2007; Reindl et al, 2009; reviewed in Kazi and Ronnstrand, 2019). Several E3 ubiquitin ligases are implicated in the downregulation of active FLT3 including CBL, SOCS2 and SOCS6 (Sargin et al, 2007, Reindl et al, 2009; Kazi and Ronnstrand, 2013; Kazi et al, 2012).
Ubiquitination of human FLT3 in COS-7 cells is abrogated by the expression of a dominant negative form of CBL, implicating CBL as a major E3 ubiquitin ligase for the FLT3 receptor (Sargin et al, 2007). While direct ubiquitination of FLT3 by SOCS2 and SOCS6 has not been demonstrated, overexpression of these E3 ligases induces FLT3 ubiquitination and internalization in cell lines (Kazi and Ronnstrand, 2012; Kazi and Ronnstrand, 2013; reviewed in Kazi and Ronnstrand, 2019).

Complex (2 results from a total of 2)

Identifier: R-HSA-9706227
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-1470001
Species: Homo sapiens
Compartment: plasma membrane

Interactor (1 results from a total of 1)

Identifier: O14512
Species: Homo sapiens
Primary external reference: UniProt: O14512

Pathway (1 results from a total of 1)

Identifier: R-HSA-1433559
Species: Homo sapiens
SCF induced proliferation is negatively regulated by various proteins including SHP1, PKC, CBL, SOCS1, SOCS6 and LNK.
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