Search results for SOS1

Showing 23 results out of 242

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Species

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Protein (3 results from a total of 3)

Identifier: R-HSA-64847
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: SOS1: Q07889
Identifier: R-HSA-983559
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: Q07889
Identifier: R-HSA-109821
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: SOS1: Q07889

Reaction (5 results from a total of 136)

Identifier: R-HSA-109813
Species: Homo sapiens
Compartment: cytosol
In the cytoplasm of unstimulated cells, SOS1 is found in a complex with GRB2. The interaction occurs between the carboxy terminal domain of SOS1 and the Src homology 3 (SH3) domains of GRB2.
Identifier: R-HSA-9703430
Species: Homo sapiens
Compartment: cytosol
Activated FTL3 fusion mutants have been shown to signal through the MAP kinase pathway as assessed through increased levels of phosphorylated ERK/MAPK proteins (Grand et al, 2007; Vu et al, 2009; Troadec et al, 2017; Chonabayashi et al, 2013; reviewed in Kazi and Roonstrand, 2019). The RAS guanine nucleotide exchange factor (GEF) SOS1 is presumed to be recruited downstream of GRB2 binding to FLT3 fusion protein, but this has not been directly demonstrated.
Identifier: R-HSA-9607301
Species: Homo sapiens
Compartment: cytosol, plasma membrane
Feline McDonough Sarcoma-like tyrosine kinase (FLT3) is a member of the class III tyrosine kinase receptor family. Ligand binding induces conformational changes in the FLT3 receptor, which facilitates its dimerization and autophosphorylation. Once fully active, FLT3 receptors can associate with growth factor receptor-bound protein 2 (GRB2), which then recruits Son of sevenless homolog 1 (SOS1). Consequently, this triggers the activation of the ERK signaling cascade (Li et al. 1993).
Identifier: R-HSA-1433471
Species: Homo sapiens
Compartment: plasma membrane, cytosol, extracellular region
Once recruited to the membrane in response to c-Kit stimulation, Son of sevenless (SOS1) activates the small GTPase protein RAS. SOS1 is a dual specificity guanine nucleotide exchange factor (GEF) that regulates both Ras and Rho family GTPases. SOS1 activates RAS by binding, which induces a conformational change that causes the exchange of GDP for GTP. RAS proteins are membrane-bound GTPases that regulate crucial cellular processes such as growth, proliferation and differentiation. Active RAS-GTP stimulates multiple effector proteins such as RAF-1, which induce a variety of cellular responses including initiation of mitogen activated protein kinase (MAPK) cascade signaling.
Identifier: R-HSA-8851859
Species: Homo sapiens
Compartment: cytosol, plasma membrane
RANBP9 binds to activated MET receptor and recruits RAS guanyl nucleotide exchange factor SOS1. RANBP9 can associate with unphosphorylated MET, but has a higher affinity for the activated receptor. The interaction involves the sprouty (SPRY) domain of RANBP9 and the tyrosine kinase domain of MET (Wang et al. 2002). RANBP9 competes with RANBP10 for MET binding. RANBP10 does not interact with SOS1, and RANBP10 binding inhibits activation of RAS downstream of MET (Wang et al. 2004).

Complex (5 results from a total of 81)

Identifier: R-HSA-109797
Species: Homo sapiens
Compartment: cytosol
Identifier: R-NUL-1250499
Species: Mus musculus, Homo sapiens
Compartment: cytosol
Identifier: R-HSA-205202
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-5637697
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-109801
Species: Homo sapiens
Compartment: cytosol

Set (3 results from a total of 3)

Identifier: R-HSA-9009718
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-9029080
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-9029079
Species: Homo sapiens
Compartment: plasma membrane

Pathway (5 results from a total of 17)

Identifier: R-HSA-9027284
Species: Homo sapiens
The RAS guanine nucleotide exchange factors SOS1 and VAV1 bind indirectly to the phosphorylated EPOR via CRKL, SHC1, and GRB2 (Miura et al. 1994, Hanazono et al. 1996, Odai et al. 1997, Arai et al. 2001, reviewed in Kuhrt et al. 2015) . The phosphorylated cytoplasmic domain of EPOR binds CRKL, which is then phosphorylated (Arai et al. 2001). Phosphorylated CRKL binds SHC1, which is then phosphorylated and binds either GRB2:SOS1 (Barber et al. 1997) or GRB2:VAV1 (Hanazono et al. 1996). SOS1 and phosphorylated VAV1 catalyze the exchange of GDP for GTP bound to RAS, that is, RAS:GDP is converted to RAS:GTP.
Identifier: R-HSA-1963640
Species: Homo sapiens
ERBB2:EGFR and ERBB2:ERBB4 can directly recruit GRB2:SOS1 complex through phosphorylated C-tail tyrosines of EGFR (Y1068 and Y1086) and ERBB2 (Y1139) that serve as docking sites for GRB2 (Xie et al. 1995, Sepp-Lorenzino et al. 1996), which, again, results in SOS1-mediated guanyl-nucleotide exchange on RAS and activation of RAF and MAP kinases (Janes et al. 1994, Sepp-Lorenzino et al. 1996).
Identifier: R-HSA-9026519
Species: Homo sapiens
Activation of the neurotrophin receptor NTRK2 (TRKB) by BDNF or NTF4 triggers downstream RAS signaling. The best studied mechanism for activation of RAS signaling downstream of NTRK2 is through SHC1-mediated recruitment of the GRB2:SOS1 complex, triggering SOS1-mediated guanine nucleotide exchange on RAS and formation of active RAS:GTP complexes (Minichiello et al. 1998, McCarthy and Feinstein 1999, Yuen and Mobley 1999).
Identifier: R-HSA-1250196
Species: Homo sapiens
Compartment: plasma membrane, cytosol, extracellular region
All ERBB2 heterodimers, ERBB2:EGFR, ERBB2:ERBB3 and ERBB2:ERBB4, are able to activate RAF/MAP kinase cascade by recruiting SHC1 (Pinkas-Kramarski et al. 1996, Sepp-Lorenzino et al. 1996) to phosphorylated C-tail tyrosine residues in either EGFR (Y1148 and Y1173), ERBB2 (Y1196, Y1221, Y1222 and Y1248), ERBB3 (Y1328) or ERBB4 (Y1188 and Y1242 in JM-A CYT1 isoform, Y1178 and Y1232 in JM-B CYT1 isoform, Y1172 and Y1226 in JM-A CYT2 isoform). SHC1 recruitment is followed by phosphorylation (Segatto et al. 1993, Soler et al. 1994), and the phosphorylated SHC1 recruits GRB2:SOS1 complex (Xie et al. 1995), which leads to SOS1-mediated guanyl-nucleotide exchange on RAS (Xie et al. 1995) and downstream activation of RAF and MAP kinases.
Identifier: R-HSA-1250347
Species: Homo sapiens
All splicing isoforms of ERBB4 possess two tyrosine residues in the C-tail that serve as docking sites for SHC1 (Kaushansky et al. 2008, Pinkas-Kramarski et al. 1996, Cohen et al. 1996). Once bound to ERBB4, SHC1 becomes phosphorylated on tyrosine residues by the tyrosine kinase activity of ERBB4, which enables it to recruit the complex of GRB2 and SOS1, resulting in the guanyl-nucleotide exchange on RAS and activation of RAF and MAP kinase cascade (Kainulainen et al. 2000).

Icon (2 results from a total of 2)

Species: Homo sapiens
Curator: Steve Jupe
Designer: Cristoffer Sevilla
SOS1 icon
Son of sevenless homolog 1

SOS

Species: Homo sapiens
Representation of Son of sevenless homolog 1 or 2
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