Search results for SPP2

Showing 5 results out of 5

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Species

Types

Compartments

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Protein (4 results from a total of 4)

Identifier: R-HSA-8956721
Species: Homo sapiens
Compartment: endoplasmic reticulum lumen
Primary external reference: UniProt: SPP2: Q13103
Identifier: R-HSA-8848900
Species: Homo sapiens
Compartment: platelet dense granule lumen
Primary external reference: UniProt: SPP2: Q13103
Identifier: R-HSA-8848914
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: SPP2: Q13103
Identifier: R-HSA-8957007
Species: Homo sapiens
Compartment: endoplasmic reticulum lumen
Primary external reference: UniProt: SPP2: Q13103

Pathway (1 results from a total of 1)

Identifier: R-HSA-5619111
Species: Homo sapiens
The genes SLC20A1 and SLC20A2 encode for phosphate transporters 1 and 2 (PiT1 and PiT2 respectively). They both have a broad tissue distribution and may play a general housekeeping role in phosphate transport such as absorbing phosphate from interstitial fluid and in extracellular matrix and cartilage calcification as well as in vascular calcification.
They possess Na+-coupled phosphate (Pi) cotransporter function with a stoichiometry of 2:1 (Na+:Pi). Defects in SLC20A2 can cause idiopathic basal ganglia calcification 1 (IBGC1; MIM:213600), an autosomal dominant disorder characterised by vascular and pericapillary calcification by calcium phosphate in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms including parkinsonism and dementia (Wang et al. 2012, Hsu et al. 2013, Ashtari et al. 2013, Forster et al. 2013).
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