Search results for SPTLC1

Showing 7 results out of 7

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Types

Compartments

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Protein (1 results from a total of 1)

Identifier: R-HSA-428155
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: SPTLC1: O15269

Interactor (2 results from a total of 2)

Identifier: O15269-2
Species: Homo sapiens
Primary external reference: UniProt: O15269-2
Identifier: Q6NUL7
Species: Homo sapiens
Primary external reference: UniProt: Q6NUL7

Complex (2 results from a total of 2)

Identifier: R-HSA-428177
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Identifier: R-HSA-428140
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane

Reaction (1 results from a total of 1)

Identifier: R-HSA-428127
Species: Homo sapiens
Compartment: cytosol, endoplasmic reticulum membrane
SPTLC (serine palmitoyltransferase) enzyme complexes associated with the endoplasmic reticulum membrane catalyze the reaction of acyl-CoA and serine to form a 3-ketosphingoid. Quantitatively, the most common ligand is palmitoyl-CoA (C16), but different isoforms of the complexes have specific activity toward the C12, C14, and C18 species (Han et al., 2009; Suzuki et al., 2022). SPTLC2 and SPTLC3 polypeptides exhibit enzyme activity when either is complexed with SPTLC1. SPTLC1 and 2 are abundant and widely expressed in human tissues, while SPTLC3 is expressed only in a smaller group of tissues and at variable levels. Analyses of complexes from cultured human cells and placenta suggested that the SPTLC heterodimers might associate with larger complexes (Hanada et al., 2000; Weiss and Stoffel, 1997; Hornemann et al. 2006, 2007; reviewed by Ikushiro & Hayashi, 2011; Lowther et al., 2012). Two novel small subunits (SPTSSA and SPTSSB) were identified, both of which enhance SPTLC activity >10-fold when bound to either of the SPTLC heterodimers (Han et al. 2009). Orosomucoid (ORM) proteins, first identified in yeast, associate with and negatively regulate SPTLC activity (Breslow et al. 2010; Han et al. 2010). The three human ORM proteins similarly bind and negatively regulate SPTLC activity (Breslow et al., 2010; reviewed by Davis et al., 2018). In particular, dysregulation of SPT activity by ORML3 appears to be involved with forms of obesity (reviewed by Brown & Spiegel, 2023). In serine deficiency, SPTLC transfers acyl-CoA onto alanine, and the resulting 1-deoxysphingoids ultimately get processed to 1-deoxyceramides (reviewed by Duan & Merrill, 2015).

Icon (1 results from a total of 1)

Species: Homo sapiens
Curator: Bruce May
Designer: Cristoffer Sevilla
SPT1 icon
Serine palmitoyltransferase 1
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