Search results for SRD5A1

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Protein (1 results from a total of 1)

Identifier: R-HSA-469657
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: SRD5A1: P18405

Reaction (1 results from a total of 1)

Identifier: R-HSA-469659
Species: Homo sapiens
Compartment: cytosol, endoplasmic reticulum membrane
The conversion of testosterone to the most potent androgen, 5-alpha-dihydrotestosterone (DHTEST), is catalyzed by microsomal 5alpha-steroid reductase 1 (SRD5A1) (Andersson & Russell 1990). SRD5A1 is expressed in the prostate and other androgen target sites. Corticotropin (Adrenocorticotropic hormone, ACTH) acts through melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al. 1997).
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