SREBP2 dimer (also called SREBF2 dimer) and, by inference SREBP1A,1C dimer, binds Importin beta-1 via the helix-loop-helix leucine zipper domain of SREBP1A,1C,2 (Nagoshi et al. 1999, Di Pardo et al. 2020).
SREBP2 (SREBF2) binds and transactivates an unusual sterol regulatory element in the promoter of the TM7SF2 gene (Schiavoni et al. 2010). NF-Y binds the promoter and is important for activation by SREBP2. SREBP1A and SREBP1C can also bind the TM7SF2 promoter (Reed et al. 2008, Rome et al. 2008).
The MVD gene is transcribed to yield mRNA and the mRNA is translated to yield protein. SREBF1A (SREBP1A) and SREBF2 (SREBP2) bind the promoter of the Diphosphomevalonate Decarboxylase (DMVD) gene and enhance transcription (Sakakura et al. 2001, Reed et al. 2008, reviewed in Horton et al. 2002).
SREBF1A (SREBP1A) and SREBF2 (SREBP2) bind the promoter of the Phosphomevalonate kinase (PMVK) gene and enhance transcription (Sakakura et al. 2001, Reed et al. 2008, reviewed in Horton et al. 2002). The PMVK gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
SREBF1A (SREBP1A) and SREBF2 (SREBP2) bind the promoter of the 7-Dehydrocholesterol Reductase (DHCR) gene and enhance transcription (Sakakura et al. 2001, Reed et al. 2008, reviewed in Horton et al. 2002). The DHCR7 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
SREBF1A (SREBP1A) and SREBF2 (SREBP2) bind the promoter of the Lathosterol oxidase gene (SC5D) and enhance transcription (Sakakura et al. 2001, Reed et al. 2008, reviewed in Horton et al. 2002). The SC5D gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
The MVK gene is transcribed to yield mRNA and the mRNA is translated to yield protein. SREBF1A (SREBP1A) and SREBF2 (SREBP2) bind the promoter of the Mevalonate kinase (MVK) gene and enhance transcription (Sakakura et al. 2001, Reed et al. 2008, reviewed in Horton et al. 2002).