Search results for STK11

Showing 14 results out of 15

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Species

Types

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Protein (4 results from a total of 4)

Identifier: R-HSA-380954
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: STK11: Q15831
Identifier: R-HSA-164119
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: STK11: Q15831
Identifier: R-HSA-6799230
Species: Homo sapiens
Compartment: azurophil granule lumen
Primary external reference: UniProt: STK11IP: Q8N1F8
Identifier: R-HSA-6806195
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: STK11IP: Q8N1F8

DNA Sequence (1 results from a total of 1)

Identifier: R-HSA-9625393
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSEMBL:ENSG00000118046

Reaction (6 results from a total of 7)

Identifier: R-HSA-6805035
Species: Homo sapiens
Compartment: nucleoplasm
In the presence of STK11 (LTKB1), TP53 associates with NUAK1 (Zeng and Berger 2006, Hou et al. 2011).
Identifier: R-HSA-3222006
Species: Homo sapiens
Compartment: nucleoplasm
STK11 (LKB1) phosphorylates NUAK1 at threonine residue T211, resulting in NUAK1 activation (Hou et al. 2011).
Identifier: R-HSA-9625378
Species: Homo sapiens
Compartment: nucleoplasm
Transcription of the STK11 (LKB1) gene, encoding Serine/threonine-protein kinase STK11 (also known as Liver kinase B1) is directly stimulated by FOXO3 and FOXO4. It is unclear if FOXO3 and FOXO4 cooperate with NF-Y and SP1, which can also bind to the STK11 gene promoter, in the induction of STK11 transcription (Lutzner et al. 2012). STK11 regulates diverse cellular processes, including apoptosis (reviewed in Zhao and Xu 2014).
Identifier: R-HSA-9625375
Species: Homo sapiens
Compartment: nucleoplasm
FOXO3 and FOXO4 bind to forkhead box elements in the promoter region of the STK11 (LKB1) gene, encoding Serine/threonine-protein kinase STK11 (also known as Liver kinase B1). The promoter of the STK11 gene also possesses binding sites for transcription factors NF-Y and SP1. It is unclear if FOXO3 and FOXO4 cooperate with NF-Y and SP1 in the induction of STK11 transcription (Lutzner et al. 2012).
Identifier: R-HSA-380942
Species: Homo sapiens
Compartment: cytosol
Upon complex formation with STRAD and MO25, LKB1 (also known as serine/threonine kinase 11, STK11) is mostly cytosolic. LKB1 attains 20x activity towards the substrates belonging to the subfamily of AMPK-like kinases (5'AMP-activated protein kinases).
Identifier: R-HSA-3222020
Species: Homo sapiens
Compartment: nucleoplasm
NUAK1, activated by STK11 (LKB1)-mediated phosphorylation on threonine residue T211, phosphorylates TP53 (p53) on serine residues S15 and S392, contributing to TP53-mediated transcriptional activation of the CDKN1A (p21) gene (Zeng and Berger 2006, Hou et al. 2011).

Complex (2 results from a total of 2)

Identifier: R-HSA-9625394
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-380967
Species: Homo sapiens
Compartment: cytosol

Pathway (1 results from a total of 1)

Identifier: R-HSA-9614657
Species: Homo sapiens
FOXO transcription factors promote expression of several pro-apoptotic genes, such as FASLG (Brunet et al. 1999, Ciechomska et al. 2003, Chen et al. 2013, Li et al. 2015), PINK1 (Mei et al. 2009, Sengupta et al. 2011), BCL2L11 (BIM) (Gilley et al. 2003, Urbich et al. 2005, Chuang et al. 2007, Hughes et al. 2011, Chen et al. 2013, Wang et al. 2016), BCL6 (Tang et al. 2002, Fernandez de Mattos et al. 2004, Shore et al. 2006) and BBC3 (PUMA) (Dudgeon et al. 2010, Hughes et al. 2011, Liu et al. 2015, Wu et al. 2016, Liu et al. 2017, Fitzwalter et al. 2018). FOXO-mediated induction of cell death genes is important during development, for example during nervous system development, where FOXO promotes neuronal death upon NGF withdrawal (Gilley et al. 2003), and also contributes to the tumor-suppressive role of FOXO factors (Arimoto Ishida et al. 2004). FOXO1 transcriptional activity is implicated in the cell death of enteric nervous system (ENS) precursors. RET signaling, which activates PI3K/AKT signaling, leading to inhibition of FOXO mediated transcription, ensures survival of ENS precursors (Srinivasan et al. 2005).
Transcription of the STK11 (LKB1) gene, encoding Serine/threonine-protein kinase STK11 (also known as Liver kinase B1), which regulates diverse cellular processes, including apoptosis, is directly stimulated by FOXO3 and FOXO4 (Lutzner et al. 2012).
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