Search results for TAT

Showing 25 results out of 63

×

Species

Types

Compartments

Reaction types

Search properties

Species

Types

Compartments

Reaction types

Search properties

Interactor (3 results from a total of 3)

TAT

Identifier: P04610
Primary external reference: UniProt: P04610

TAT

Identifier: P04326
Primary external reference: UniProt: P04326
Identifier: O12161
Primary external reference: UniProt: O12161

Protein (3 results from a total of 9)

Identifier: R-HSA-71152
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: TAT: P17735
Identifier: R-HSA-535508
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: TATDN2: Q93075
Identifier: R-HSA-68774
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: PSMC3: P17980

Complex (3 results from a total of 11)

Identifier: R-HSA-71153
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-167185
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-167184
Species: Homo sapiens
Compartment: nucleoplasm

RNA Sequence (2 results from a total of 2)

Identifier: R-HSA-9708335
Species: Homo sapiens
Compartment: cytosol
Primary external reference: RNAcentral: tRNA Ile TAT: URS0000757938_9606
Identifier: R-HSA-9708325
Species: Homo sapiens
Compartment: cytosol
Primary external reference: RNAcentral: URS0000757938_9606

Reaction (3 results from a total of 18)

Identifier: R-HSA-167234
Species: Homo sapiens
Compartment: nucleoplasm
Tat associates with the Cyclin T1 subunit of P-TEFb (Cyclin T1:Cdk9) through a region of cysteine-rich and core sequences referred to as the ARM domain within Tat (Wei et al., 1998; see also Herrmann 1995). This interaction is believed to involve metal ions stabilized by cysteine residues in both proteins (Bieniasz et al., 1998; Garber et al., 1998).
Identifier: R-HSA-167459
Species: Homo sapiens
Compartment: nucleoplasm
At the beginning of this reaction, 1 molecule of 'HIV-1 Tat-containing arrested processive elongation complex' is present. At the end of this reaction, 1 molecule of 'HIV-1 Tat-containing aborted elongation complex after arrest' is present.
This reaction takes place in the 'nucleus'.
Identifier: R-HSA-1791156
Species: Homo sapiens
Compartment: nucleoplasm
The TATDN2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.

Pathway (3 results from a total of 12)

Identifier: R-HSA-176034
Species: Homo sapiens
Compartment: nucleoplasm
The elongation of HIV-1 mRNA depends upon the interaction of Tat with the host P-TEFb complex (Hermann and Rice, 1995; Wei et al., 1998).
Identifier: R-HSA-167200
Species: Homo sapiens
Compartment: nucleoplasm
This HIV-1 event was inferred from the corresponding human RNA Poll II transcription event in Reactome. The details relevant to HIV-1 are described below. For a more detailed description of the general mechanism, see the link to the corresponding RNA Pol II transcription event below. The formation of the HIV-1 elongation complex involves Tat mediated recruitment of P-TEFb(Cyclin T1:Cdk9) to the TAR sequence (Wei et al, 1998) and P-TEFb(Cyclin T1:Cdk9) mediated phosphorylation of the RNA Pol II CTD as well as the negative transcriptional elongation factors DSIF and NELF (Herrmann, 1995; Ivanov et al. 2000; Fujinaga et al. 2004; Zhou et al., 2004).
Identifier: R-HSA-167242
Species: Homo sapiens
Compartment: nucleoplasm
This event was inferred from the corresponding Reactome human Poll II transcription elongation event. The details specific to HIV-1 transcription elongation are described below. In the absence of the HIV-1 Tat protein, the RNA Pol II complexes associated with the HIV-1 template are non-processive. RNA Pol II is arrested after promoter clearance by the negative transcriptional elongation factors DSIF and NELF as occurs during early elongation of endogenous templates (Wada et al, 1998; Yamaguchi et al. 1999). This arrest cannot be overcome by P-TEFb mediated phosphorylation in the absence of Tat however, and elongation aborts resulting in the accumulation of short transcripts (Kao et al., 1987).

DNA Sequence (1 results from a total of 1)

Identifier: R-HSA-5642210
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSG00000157014

Chemical Compound (3 results from a total of 3)

Identifier: R-ALL-3296446
Compartment: extracellular region
Primary external reference: ChEBI: tatridin B: 73239
Identifier: R-ALL-214401
Compartment: cytosol
Primary external reference: ChEBI: tat-BP: 46763
Identifier: R-ALL-205686
Compartment: extracellular region
Primary external reference: ChEBI: 46763

Person (3 results from a total of 3)

Authored Pathways: 0
Reviewed Pathways: 1
Authored Reactions: 0
Reviewed Reactions: 6
Authored Pathways: 1
Reviewed Pathways: 0
Authored Reactions: 0
Reviewed Reactions: 0
Authored Pathways: 0
Reviewed Pathways: 1
Authored Reactions: 0
Reviewed Reactions: 0

Icon (1 results from a total of 1)

tat

Species: Homo sapiens
Curator: Marc Gillespie
Designer: Cristoffer Sevilla
tat icon
Protein Tat is a nuclear transcriptional activator of viral gene expression and is essential for viral transcription from the LTR promoter and replication
Cite Us!