Search results for TBXAS1

Showing 10 results out of 10

×

Species

Types

Compartments

Reaction types

Search properties

Species

Types

Compartments

Reaction types

Search properties

Protein (5 results from a total of 5)

Identifier: R-HSA-65976
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: TBXAS1: P24557
Identifier: R-HSA-5603378
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: TBXAS1: P24557
Identifier: R-HSA-5603341
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: P24557
Identifier: R-HSA-5603356
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: P24557
Identifier: R-HSA-5603342
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: P24557

Set (1 results from a total of 1)

Identifier: R-HSA-5603369
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane

Reaction (3 results from a total of 3)

Identifier: R-HSA-76500
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane, endoplasmic reticulum lumen
Thromboxane synthase (TBXAS1) aka CYP5A1 mediates the isomerisation of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2) (Miyata et al. 2001, Chevalier et al. 2001). This reaction is not coupled with any P450 reductase proteins nor consumes NADPH.
Identifier: R-HSA-2161613
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane, endoplasmic reticulum lumen
Thromboxane synthase (TBXAS1) aka CYP5A1 facilitates rearrangement of the PGH2 endoperoxide bridge by a complementary mechanism to prostacyclin synthase, interacting with the C-9 oxygen to promote endoperoxide bond cleavage. The C-11 oxygen radical initiates intramolecular rearrangement, resulting in either the formation of thromboxane A2 (TXA2) or 12-hydroxyheptadecatrienoic acid (12S-HHT) and malonaldehyde (MDA) (Wang et al. 2001).
Identifier: R-HSA-5603275
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane, endoplasmic reticulum lumen
Thromboxane-A synthase (TBXAS1), an enzyme of the arachidonic acid cascade, produces thromboxane A2 (TXA2) from prostaglandin H2 (PGH2). Together with prostacyclin (PGI2), TXA2 plays a key role in the maintenance of haemostasis. It is also a constrictor of vascular and respiratory smooth muscle and implicated in the induction of osteoclast differentiation and activation. Defects in TBXAS1 can cause Ghosal hematodiaphyseal dysplasia (GHDD; MIM:231095), a rare autosomal recessive disorder characterised by increased bone density with predominant diaphyseal involvement and aregenerative anemia, a bone marrow failure where functional marrow cells are regenerated slowly or not at all. Mutations that can cause GHDD are L488P, L83P, G482W and R413E (Genevieve et al. 2008).

Pathway (1 results from a total of 1)

Identifier: R-HSA-5579032
Species: Homo sapiens
Thromboxane-A synthase (TBXAS1), an enzyme of the arachidonic acid cascade, produces thromboxane A2 (TXA2) from prostaglandin H2 (PGH2). Together with prostacyclin (PGI2), TXA2 plays a key role in the maintenance of haemostasis. It is also a constrictor of vascular and respiratory smooth muscle and implicated in the induction of osteoclast differentiation and activation. Defects in TBXAS1 can cause Ghosal hematodiaphyseal dysplasia (GHDD; MIM:231095), a rare autosomal recessive disorder characterised by increased bone density with predominant diaphyseal involvement and aregenerative anemia, a bone marrow failure where functional marrow cells are regenerated slowly or not at all (Genevieve et al. 2008).
Cite Us!