Search results for TDRD6

Showing 4 results out of 4

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Species

Types

Compartments

Reaction types

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Protein (1 results from a total of 1)

Identifier: R-HSA-5603052
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: TDRD6: O60522

Complex (1 results from a total of 1)

Identifier: R-HSA-5603053
Species: Homo sapiens
Compartment: cytosol

Reaction (2 results from a total of 2)

Identifier: R-HSA-5601888
Species: Homo sapiens
Compartment: cytosol
As inferred from mouse homologs, after binding PIWIL1 (HIWI in human, Miwi in mouse) the 3' end of the pre-piRNA is trimmed by an unknown nuclease. The final size of the piRNA appears to be determined by the particular PIWI protein with which it is associated. PIWIL1 and TDRD6 are located in the chromatoid body. Both TDRD6 and TDRKH are associated with PIWIL1 in adult testes but only TDRKH is present in embryonic prospermatogonia. TDRKH is required for spermatogenesis and appears to participate in trimming of the 3' end of pre-piRNAs.
Identifier: R-HSA-5615682
Species: Homo sapiens
Compartment: cytosol
After cleavage by PLD6 at the 5' end, the pre-piRNA is bound by PIWIL1 (HIWI, homolog of MIWI in mouse), likely in a complex with other proteins such as TDRD6 and TDRKH, which interact with methylated arginine residues on PIWIL1 and are required for piRNA biogenesis. Binding by PIWIL1 is believed to be selective for pre-piRNAs that have uracil residues at their 5' ends.
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