Search results for TEAD2

Showing 9 results out of 9

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Species

Types

Compartments

Reaction types

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Protein (1 results from a total of 1)

Identifier: R-HSA-2032763
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: TEAD2: Q15562

Interactor (1 results from a total of 1)

Identifier: Q15562-2
Species: Homo sapiens
Primary external reference: UniProt: Q15562-2

Reaction (3 results from a total of 3)

Identifier: R-HSA-8871260
Species: Homo sapiens
Compartment: nucleoplasm
The YAP1 transcriptional coactivator can bind any one of the four TEAD transcription factors to form a complex. The stoichiometry of this complex is unknown (Chan et al. 2009).
Identifier: R-HSA-8951695
Species: Homo sapiens
Compartment: nucleoplasm
The complex of YAP1 and one TEAD proteins (TEAD1, TEAD2, TEAD3 or TEAD4) binds to TEAD-binding sites in the promoter of the CTGF gene (Zhao et al. 2008). Association of RUNX3 with the TEADs:YAP1 complex inhibits loading of the TEADs:YAP1 to the CTGF promoter (Qiao et al. 2016).
Identifier: R-HSA-8951676
Species: Homo sapiens
Compartment: nucleoplasm
RUNX3 interacts with both YAP1 and TEAD proteins. The interaction with YAP1 involves the PY motif of RUNX3 and the WW domain of YAP1. The interaction with TEADs involves the Runt domain of RUNX3 and the DNA recognition helix of TEADs. RUNX3 was shown to directly interact with TEAD1 and TEAD4. Based on sequence similarity, it is highly probable that RUNX3 also interacts with TEAD2 and TEAD3. The interaction of RUNX3 with YAP1 and/or TEADs does not prevent formation of the YAP1:TEADs complex (Yagi et al. 1999, Qiao et al. 2015).

Complex (3 results from a total of 3)

Identifier: R-HSA-8869640
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-8951678
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-8951679
Species: Homo sapiens
Compartment: nucleoplasm

Set (1 results from a total of 1)

Identifier: R-HSA-8951677
Species: Homo sapiens
Compartment: nucleoplasm
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