Search results for TEK

Showing 19 results out of 22

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Types

Compartments

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Protein (2 results from a total of 2)

TEK

Identifier: R-HSA-197755
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: Q02763
Identifier: R-HSA-204772
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: TEK: Q02763

Complex (6 results from a total of 6)

Identifier: R-HSA-204807
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-210862
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-204789
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-204810
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-204783
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-204857
Species: Homo sapiens
Compartment: plasma membrane

Interactor (4 results from a total of 4)

Identifier: Q9BXF9
Species: Homo sapiens
Primary external reference: UniProt: Q9BXF9
Identifier: Q8WW24
Species: Homo sapiens
Primary external reference: UniProt: Q8WW24
Identifier: Q96M29
Species: Homo sapiens
Primary external reference: UniProt: Q96M29
Identifier: Q969V4
Species: Homo sapiens
Primary external reference: UniProt: Q969V4

Reaction (6 results from a total of 9)

Identifier: R-HSA-210974
Species: Homo sapiens
Compartment: cytosol, plasma membrane
Grb2 binds directly to autophosphorylated Tie2 receptor. GRB2 also contains two SH3 domains, which bring various ligands to the sites of active signaling. One of the SH3 domains on Tie2-bound Grb2 recruits SOS1, an activating nucleotide exchange factor for Ras. This interaction of Sos1 to Grb2 brings Sos1 towards Ras molecules leading to Ras activation. Ras is implicated in the MAP kinase cascade, a pathway in cell growth stimulation, migration and differentiation.
Identifier: R-HSA-204871
Species: Homo sapiens
Compartment: plasma membrane, cytosol
Tie2/Tek provide mitogenic signals to endothelial cells by promoting the association of Grb2 to one of their phosphotyrosines. Grb2 is an adaptor protein that has been linked to activation of Ras and mitogen activated protein kinase (MAPK) cell growth signaling pathways. Grb2 also binds to the Y1102 of the kinase domain of Tie2 with one of its SH2 doamins.
Identifier: R-HSA-204873
Species: Homo sapiens
Compartment: plasma membrane, cytosol
Shp2 interact with Tyr816 in the juxtamembrane region and Tyr1108 and Tyr1113, respectively, in the C-terminal tail region of Tie2/Tek.
Identifier: R-HSA-204824
Species: Homo sapiens
Compartment: extracellular region, plasma membrane
Ang4 represents a third protein of the Ang family that binds to the Tie2 receptor. The mouse Ang3 and human Ang4 are interspecies orthologs. Ang4 acts as an activating ligand and induces phosphorylation in Tie2.
Identifier: R-HSA-204773
Species: Homo sapiens
Compartment: plasma membrane, cytosol
Grb7 was initially identified as an EGF receptor binding protein and thereafter many binding partners have been reported. Grb7 interacts with Tie2/Tek in a phosphotyrosine-dependent manner through its SH2 domain.
Identifier: R-HSA-204813
Species: Homo sapiens
Compartment: plasma membrane, cytosol
Grb14 is also one of the signaling partners of Tie2. The SH2 domain of Grb2 mediates binding to Tie2. It binds residues Y816, Y1108 and Y1113 respectively, in the C-terminal tail region of Tie2/Tek.

Pathway (1 results from a total of 1)

Identifier: R-HSA-210993
Species: Homo sapiens
The Tie2/Tek receptor tyrosine kinase plays a pivotal role in vascular and hematopoietic development and is expressed exclusively on endothelial lineage. Tie2 interacts with a group of ligands belonging to angiopoietin family and undergoes activation.
These ligands show opposing actions, angiopoietin 1 and angiopoietin 4 stimulate the Tie2 phosphorylation and angiopoietin 2 inhibits it. Upon tyrosine phosphorylation Tie2 acts as a scaffold for various signaling proteins involved in different signal transduction cascades that can effect survival of endothelium and angiogenic sprout formation.
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