Search results for TES

Showing 17 results out of 33

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Species

Types

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Chemical Compound (3 results from a total of 4)

TES

Identifier: R-ALL-30321
Compartment: endoplasmic reticulum lumen
Primary external reference: ChEBI: testosterone: 17347
Identifier: R-ALL-193057
Compartment: cytosol
Primary external reference: ChEBI: testosterone: 17347
Identifier: R-ALL-5618089
Compartment: nucleoplasm
Primary external reference: ChEBI: 17347

Protein (1 results from a total of 1)

Identifier: R-HSA-446396
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: TESK1: Q15569

Interactor (1 results from a total of 1)

Identifier: Q96S53
Species: Homo sapiens
Primary external reference: UniProt: Q96S53

ChemicalDrug (1 results from a total of 1)

Identifier: R-ALL-9646810
Compartment: cytosol

Reaction (3 results from a total of 18)

Identifier: R-HSA-9690404
Species: Homo sapiens
Compartment: nucleoplasm
Subsequent to SRY expression in the gonadal ridge, the SOX9 gene is transcribed to yield mRNA and the mRNA is translated to yield SOX9 protein (Knower et al. 2011, Croft et al. 2018). SRY and NR5A1 (SF1) bound at the TES enhancer (Knower et al. 2011) and the eALDI enhancer (upstream of the TES enhancer, Croft et al. 2018) of the SOX9 gene initially activate transcription of SOX9 (Knower et al. 2011, Croft et al. 2018, and inferred from mouse homologs). Later, SOX9 and NR5A1 activate the TES enhancer, providing a mechanism for autoregulation (Knower et al. 2011). DMRT1, itself directly activated by SOX9, also directly activates SOX9 (inferred from mouse homologs). FGF9 acting through FGFR2 (inferred from mouse homologs) and Prostaglandin D2 (Malki et al. 2005), the product of PTGDS, activate SOX9 through less well characterized mechanisms.
Identifier: R-HSA-446372
Species: Homo sapiens
Compartment: cytosol
The association of PARVA with TESK1 appears to suppress cell spreading (Lalonde et al. 2005). TESK1 can phosphorylate cofilin and promote F-actin polymerization and cell spreading (Tsumura et al., 2005 ; Toshima et al., 2001; Leeksma et al., 2002). PARVA associates with testicular protein kinase 1 (TESK1) and inhibits its activity (Lalonde et al. 2005).
Identifier: R-HSA-9705714
Species: Homo sapiens
Compartment: cytosol, endoplasmic reticulum membrane
The conversion of testosterone (TEST) to the most potent androgen, 5-alpha-dihydrotestosterone (DHTEST), is catalyzed by microsomal 5alpha-steroid reductase 3 (SRD5A3) (Uemura et al. 2008). SRD5A3 is expressed in the prostate and other androgen target sites. Corticotropin (Adrenocorticotropic hormone, ACTH) acts through melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al. 1997).

RNA Sequence (2 results from a total of 2)

Identifier: R-HSA-6793006
Species: Homo sapiens
Compartment: mitochondrial matrix
Primary external reference: ENSEMBL: ENST00000387459
Identifier: R-HSA-6793003
Species: Homo sapiens
Compartment: mitochondrial matrix
Primary external reference: ENSEMBL: ENST00000387459

Set (2 results from a total of 2)

Identifier: R-HSA-9649466
Species: Homo sapiens
Compartment: plasma membrane

Pathway (2 results from a total of 2)

Identifier: R-HSA-9690406
Species: Homo sapiens
In humans, primordial germ cells (PGCs) are specified about 2 weeks after fertilization, a time before gastrulation (reviewed in Svingen and Koopman 2013, Mäkelä et al. 2019). PGCs are initially located extraembryonically and then migrate to colonize the gonadal ridges (genital ridges) of the embryo during the fifth week after fertilization. At this time, either ovaries and testes can originate from the gonadal ridges. That is, the cells of the gonadal ridges are initially bipotential and remain bipotential until about 42 days after conception, when transient expression of the SRY gene located on the Y chromosome in male embryos is initiated in some somatic cells of the gonadal primordium (reviewed in Sekido and Lovell-Badge 2013, Barrionuevo et al. 2013, Svingen et al. 2013, Mäkelä et al. 2019).
The transcription factors WT1, GATA4, ZFPM2 (FOG2), and the nuclear receptor NR5A1 (SF1) activate transcription of SRY (Shimamura et al. 1997, Hossain and Saunders 2001, De Santa Barbara et al. 2001, Miyamoto et al. 2008, and inferred from mouse homologs). SRY and NR5A1 then activate transcription of SOX9, one of the master regulators of testis development and maintenance (Knower et al. 2011, Croft et al. 2018, inferred from mouse homologs, reviewed in Gonen and Lovell-Badge 2019). Regulation of genes by SRY and then, when expression of SRY decreases, by SOX9 causes the specification of Sertoli cells that further organize formation of the testis by encasing the primordial germ cells in protocords, which then form fully developed testis cords.
SOX9 directly activates its own promoter to maintain SOX9 expression through development and into adulthood (Croft et al. 2018, and inferred from mouse homologs). SOX9 and GATA4 directly activate DMRT1 (inferred from mouse homologs), which maintains testis specification by maintaining expression of SOX9 and other testis-related genes. DMRT1 also acts to suppress ovarian specification by binding and repressing FOXL2 and WNT4 genes (inferred from mouse homologs). SOX9 directly activates FGF9 (inferred from mouse homologs), which acts via FGFR2 to maintain SOX9 expression, and PTGDS (inferred from mouse homologs), which converts Prostaglandin H2 to Prostaglandin D2, a critical hormone-like lipid that recruits supporting cells to Sertoli cells and acts indirectly to maintain SOX9 expression. SOX9, NR5A1, and GATA4 directly activate AMH (De Santa Barbara et al. 1998, and inferred from mouse homologs), an extracellular signaling molecule which causes regression of the Muellerian duct of the female reproductive system. SOX9 also directly activates many other genes, including DHH (Rahmoun et al. 2017, and inferred from mouse homologs), an intercellular signaling molecule required for testis formation.
Identifier: R-HSA-9665245
Species: Homo sapiens
This pathway describes resistance of ERBB2 KD mutants to tyrosine kinase inhibitor tesevatinib (Trowe et al. 2018).

Complex (1 results from a total of 1)

Identifier: R-HSA-372869
Species: Homo sapiens
Compartment: cytosol

Icon (1 results from a total of 1)

Species: Homo sapiens
Curator: Bruce May
Designer: Cristoffer Sevilla
MT-TE icon
mitochondrially encoded tRNA-Glu (GAA/G)
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