Search results for TFR2

Showing 3 results out of 3

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Species

Types

Compartments

Reaction types

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Protein (1 results from a total of 1)

Identifier: R-HSA-5691118
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: TFR2: Q9UP52

Complex (1 results from a total of 1)

Identifier: R-HSA-5691094
Species: Homo sapiens
Compartment: plasma membrane

Reaction (1 results from a total of 1)

Identifier: R-HSA-5691150
Species: Homo sapiens
Compartment: extracellular region, plasma membrane
Transferrin receptor 2 (TFR2) is highly expressed in liver and erythroid precursor cells and is a close homologue of human transferrin receptor 1 (TFRC). Transferrin (TF), loaded with iron (holoTF), transports two ferric iron ions through the blood. Two holoTFs bind to a TFR2 dimer (with lower affinity than to TFRC) and mediates cellular uptake of holoTF in a non-iron dependent manner (Kawabata et al. 1999, Trinder & Baker 2003). Defects in TFR2 can cause hemochromatosis 3 (HFE3; MIM:604250), an iron metabolism disorder characterised by iron overload. Excess iron is deposited over decades in a variety of organs leading to their failure, resulting in serious illnesses including cirrhosis, hepatomas, diabetes, cardiomyopathy, arthritis and hypogonadotropic hypogonadism (Camaschella et al. 2000, Wallace & Subramaniam 2007).
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