Search results for THEM4

Showing 13 results out of 13

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Species

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Species

Types

Compartments

Reaction types

Search properties

Protein (3 results from a total of 3)

Identifier: R-HSA-6809345
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: THEM4: Q5T1C6
Identifier: R-HSA-162408
Species: Homo sapiens
Compartment: mitochondrial matrix
Primary external reference: UniProt: THEM4: Q5T1C6
Identifier: R-HSA-199437
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: THEM4: Q5T1C6

Complex (3 results from a total of 3)

Identifier: R-HSA-5690395
Species: Homo sapiens
Compartment: mitochondrial matrix
Identifier: R-HSA-199453
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-162401
Species: Homo sapiens
Compartment: cytosol

Set (4 results from a total of 4)

Identifier: R-HSA-5690052
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-2400007
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-162414
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-5690051
Species: Homo sapiens
Compartment: mitochondrial matrix

Reaction (3 results from a total of 3)

Identifier: R-HSA-199443
Species: Homo sapiens
Compartment: plasma membrane
The phosphorylation of membrane-recruited AKT at threonine and serine can be inhibited by direct binding of two different proteins, C-terminal modulator protein (THEM4 i.e. CTMP), which binds to the carboxy-terminal tail of AKT (Maira et al. 2001), or Tribbles homolog 3 (TRIB3), which binds to the catalytic domain of AKT (Du et al. 2003).
Identifier: R-HSA-5690066
Species: Homo sapiens
Compartment: mitochondrial matrix
The maintenance/regulation of cellular levels of free fatty acids and fatty acyl-CoAs (the activated form of free fatty acids) is extremely important, as imbalances in lipid metabolism can have serious consequences for human health. Acyl-coenzyme A thioesterases (ACOTs) hydrolyse the thioester bond in medium- to long-chain fatty acyl-CoAs (of C12-C18 lengths) (MCFA-CoA, LCFA-CoA) to their free fatty acids (MCFA, LCFA) (Cohen 2013, Hunt et al. 2012, Kirkby et al. 2010). ACOTs that function in the mitochondrion are ACOT2 (Hunt et al. 2006), ACOT9 (Kirkby et al. 2010), THEM4 dimer (Zhuravleva et al. 2012, Zhao et al. 2012) and THEM5 dimer (Zhuravleva et al. 2012). THEM4 is also functional in the cytosol and at the plasma membrane (Cohen 2013).
Identifier: R-HSA-109700
Species: Homo sapiens
Compartment: plasma membrane, cytosol
The phosphorylation of membrane-recruited AKT at threonine and serine can be inhibited by direct binding of two different proteins, C-terminal modulator protein (THEM4 i.e. CTMP), which binds to the carboxy-terminal tail of AKT (Maira et al. 2001), or Tribbles homolog 3 (TRIB3), which binds to the catalytic domain of AKT (Du et al. 2003).
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